Phospholipid analogs as diapeutic agents and methods thereof
The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
1. A method for the treatment of a cancer in a subject comprising:
administering, to a subject previously diagnosed with cancer, an effective amount of 125 I-labeled 18-(p-iodophenyl)octadecyl phosphocholine or a salt thereof for treating the cancer.
2. The method of claim 1 , wherein the subject is human.
3. The method of claim 1 , wherein the phosphocholine is selectively uptaken by cancer cells within the subject.
4. The method of claim 1 , wherein the cancer is lung cancer.
5. The method of claim 1 , wherein the cancer is adrenal cancer.
6. The method of claim 1 , wherein the cancer is melanoma or subcutaneous cancer.
7. The method of claim 1 , wherein the cancer is intestinal cancer, colon cancer or colorectal cancer.
8. The method of claim 1 , wherein the cancer is ovarian cancer or cervical cancer.
9. The method of claim 1 , wherein the cancer is prostate cancer.
10. The method of claim 1 , wherein the cancer is liver cancer or hepatocellular carcinoma.
11. The method of claim 1 , wherein the cancer is squamous cell carcinoma.
12. The method of claim 1 , wherein the cancer is retinoblastoma.
13. The method of claim 1 , wherein the cancer is glioma.
14. The method of claim 1 , wherein the cancer is breast cancer.
15. The method of claim 1 , wherein the cancer is carcinosarcoma.
16. The method of claim 1 , wherein the cancer is pancreatic cancer.
17. The method of claim 1 , comprising administering between about 0.5 μCi and about 500 mCi of the 125 I-labeled 18-(p-iodophenyl)octadecyl phosphocholine to the subject.
18. The method of claim 1 , comprising administering less than 0.3 μg/kg of body weight of the 125 I-labeled 18-(p-iodophenyl)octadecyl phosphocholine to the subject.
19. A method for the treatment of a cancer in a subject comprising:
administering, to a subject previously diagnosed with as having cancer, an effective amount of 131 I-labeled 18-(p-iodophenyl)octadecyl phosphocholine or a salt thereof for treating the cancer.
20. The method of claim 19 , wherein the subject is human.
21. The method of claim 19 , wherein the phosphocholine is selectively uptaken by cancer cells within the subject.
22. The method of claim 19 , wherein the cancer is lung cancer.
23. The method of claim 19 , wherein the cancer is adrenal cancer.
24. The method of claim 19 , wherein the cancer is melanoma or subcutaneous cancer.
25. The method of claim 19 , wherein the cancer is intestinal cancer, colon cancer or colorectal cancer.
26. The method of claim 19 , wherein the cancer is ovarian cancer or cervical cancer.
27. The method of claim 19 , wherein the cancer is prostate cancer.
28. The method of claim 19 , wherein the cancer is liver cancer or hepatocellular carcinoma.
29. The method of claim 19 , wherein the cancer is squamous cell carcinoma.
30. The method of claim 19 , wherein the cancer is retinoblastoma.
31. The method of claim 19 , wherein the cancer is glioma.
32. The method of claim 19 , wherein the cancer is breast cancer.
33. The method of claim 19 , wherein the cancer is carcinosarcoma.
34. The method of claim 19 , wherein the cancer is pancreatic cancer.