IP Library › Granted Patent US 9,562,066
Granted Patent B2
US 9,562,066 · App. 14/036,960 · Granted Feb 7, 2017

Oral therapy of necrotizing enterocolitis

Inventor: David J. Hackam (Pittsburgh, PA)
Assignee: University of Pittsburgh-Of the Commonwealth System of Higher Education
C07H21/04A23L33/17A23L33/40A61K31/711A61K45/06
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Quick Facts
Patent No.
US 9,562,066
App. No.
14/036,960
Granted
Feb 7, 2017
Kind
B2
Abstract

The present invention relates to methods of treating or reducing the risk of necrotizing enterocolitis (NEC) in an infant comprising orally administering an effective amount of a CpG-ODN. It is based, at least in part, on the results of experiments in which orally administered CpG-ODNs were observed to reduce the histopathology and markers of inflammation in a murine model for NEC. The present invention further provides for oral formulations of CpG-ODN for administration to infants.

Claims (6)

1. An infant nutritional formula comprising a therapeutically effective amount of a CpG-ODN comprising 5′ TCGTCGTTTTGTCGTTCCTGACGTT 3′ (SEQ ID NO:9), further comprising nutrients selected from the group consisting of proteins, lipids, carbohydrates, electrolytes, and vitamins.

2. The infant nutritional formula of claim 1 , where the formula is nutritionally complete.

3. The infant nutritional formula of claim 1 , where the concentration of CpG-ODN provides a daily dose of between about 0.1-10 mg/kg.

4. The infant nutritional formula of claim 3 where the daily dose provided is about 1 mg/kg.

5. The infant nutritional formula of claim 1 , where the CpG-ODN is comprised in a particle selected from the group consisting of a micelle, liposome, microsphere or nanoparticle.

6. The infant nutritional formula of claim 1 , wherein the CpG-ODN comprises one or more phosphorothioate linkage.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2016
From: HACKAM, DAVID J.
To: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
Reel/Frame 039776/0161 →
CONFIRMATORY LICENSE Recorded Dec 17, 2013
From: UNIVERSITY OF PITTSBURGH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031832/0139 →
Continuity (2)
Provisional Application 61705401 · Sep 25, 2012
Related Publication 20140086982A1 · Mar 27, 2014