C5AR antagonists
Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activation of C5a receptors.
1. A compound having the formula
or a pharmaceutically acceptable salt, hydrate, or rotamer thereof.
2. A compound having the formula
3. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 1 or 2 or a pharmaceutically acceptable salt thereof.
4. A method of treating a disease or disorder selected from the group consisting of vasculitis, immunovasculitis, Wegener's granulomatosis, microscopic polyangiitis, and glomerulonephritis, in a patient in need thereof comprising administering a C5a receptor inhibitory effective amount of a compound of claim 1 or a pharmaceutically acceptable salt, hydrate or rotamer thereof.
5. The method of claim 4 , wherein the disease or disorder is vasculitis.
6. The method of claim 4 , wherein the disease or disorder is immunovasculitis.
7. The method of claim 4 , wherein the disease or disorder is Wegener's granulomatosis.
8. The method of claim 4 , wherein the disease or disorder is microscopic polyangiitis.
9. The method of claim 4 , wherein the disease or disorder is glomerulonephritis.