IP Library › Granted Patent US 9,580,459
Granted Patent B2
US 9,580,459 · App. 14/261,963 · Granted Feb 28, 2017

Water-soluble ursodeoxycholic acid prodrugs

Inventors: Peter Ian Dosa (Vadnais Heights, MN); Clifford John Steer (Eagan, MN); Ingrid Gunda Georg (St. Paul, MN)
Assignee: Metselex, Inc.
C07J51/00
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Quick Facts
Patent No.
US 9,580,459
App. No.
14/261,963
Granted
Feb 28, 2017
Kind
B2
Abstract

Ursodeoxycholic acid (UDCA) is a bile acid with demonstrated anti-apoptotic activity in both in vitro and in vivo models. Water-soluble prodrugs of UDCA for use in indications where intravenous administration of UDCA may be preferable, such as reducing damage from stroke or acute kidney injury, are disclosed. The disclosed prodrugs showed significant anti-apoptotic activity in a series of in vitro assays.

Claims (10)

1. A compound having the general formula

or a pharmaceutically acceptable salt thereof.

2. A compound having the general formula

or a pharmaceutically acceptable salt thereof.

3. A compound having the general formula

or a pharmaceutically acceptable salt thereof.

4. The disodium salt of the molecule having the general formula

5. The tris(hydroxymethyl)aminomethane salt of the molecule having the general formula

6. The di-tris(hydroxymethyl)aminomethane salt of the molecule having the general formula

7. The diisopropylamine salt of the molecule having the general formula

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2021
From: DOSA, PETER IAN; STEER, CLIFFORD; GEORG, INGRID GUNDA
To: METSELEX, INC.
Reel/Frame 057186/0607 →
Continuity (2)
Provisional Application 61816204 · Apr 26, 2013
Related Publication 20140323748A1 · Oct 30, 2014