Lithium co-crystals and an additional neuropsychiatric agent for treatment of neuropsychiatric disorders
The invention concerns methods and compositions for treating a neuropsychiatric disorder, wherein the method comprises administering an effective amount of a co-crystal of lithium to a subject in need thereof, wherein the co-crystal comprises lithium, or a pharmaceutically acceptable salt thereof, and an amino acid.
1. A method for treating a neuropsychiatric disorder, comprising administering an effective amount of a co-crystal of lithium to a subject having the neuropsychiatric disorder, wherein the co-crystal comprises lithium, or a pharmaceutically acceptable salt thereof, and an amino acid; and administering an additional agent for treating the neuropsychiatric disorder before, during, or after the administration of the lithium co-crystal.
2. The method of claim 1 , wherein the co-crystal comprises a pharmaceutically acceptable salt of lithium, and an amino acid.
3. The method of claim 1 , wherein the pharmaceutically acceptable salt is lithium salicylate or lithium hydroxide.
4. The method of claim 1 , wherein the amino acid is L-proline.
5. The method of claim 1 , wherein the co-crystal comprises lithium salicylate and L-proline.
6. The method of claim 1 , wherein the neuropsychiatric disorder is a neurodegenerative disorder.
7. The method of claim 6 , wherein the neurodegenerative disorder is Alzheimer's disease, Parkinson's disease, or amyotrophic laterals sclerosis (ALS).
8. The method of claim 1 , wherein the neuropsychiatric disorder is a mood disorder, schizoaffective disorder, tic disorder, or suicidality.
9. The method of claim 1 , wherein the neuropsychiatric disorder is Alzheimer's disease or other dementia, and the additional agent is a cholinesterase inhibitor, N-methyl D-aspartate antagonist, vitamin E, or a combination of two or more of the foregoing.
10. The method of claim 9 , wherein the additional agent is donepezil, rivastigmine, galantamine, memantine, or a combination of two or more of the foregoing.
11. The method of claim 1 , wherein the additional agent is an anti-depressant, anti-convulsant, or mood stabilizer.
12. The method of claim 1 , wherein the additional agent is a selective serotonin reuptake inhibitor (SSRI), serotonin-noroepinephrine reuptake inhibitor (SNRI), serotonin antagonist and reuptake inhibitor (SARI), monamine oxidase inhibitor (MAOI), carboxamide, fructose derivative, triazine, or a combination of two or more of the foregoing.
13. The method of claim 1 , wherein the lithium co-crystal is administered to the subject in a composition comprising the lithium co-crystal and a pharmaceutically acceptable carrier.