Compounds for inflammation and immune-related uses

1. A compound selected from the group consisting of:

Number

Structure

Compound Name

1.

N-(5-(2-chloro-5-( 1 H-pyrazol-4- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide

2.

N-(5-(2-ethoxy-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide

3.

N-(5-(2-chloro-5-(2-methylthiazol-4- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide

6.

5-fluoro-N-(5-(2-methoxy-5-(1-methyl- 1 H-pyrazol-4-yl)phenyl)pyrazin- 2-yl)-4-methylnicotinamide

8.

N-(5-(2-ethyl-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide

14.

N-(5-(2-chloro-5-(5-methylthiazol-2- yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide

16.

N-(5-(2-chloro-5-(pyrimidin-2- yloxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide

19.

N-(5-(2-isopropoxy-5-(1-methyl- 1 H-pyrazol-4-yl)phenyl)pyrazin-2- yl)-4-methylnicotinamide

22.

5-fluoro-4-methyl-N-(5-(5-(1-methyl- 1 H-pyrazol-4-yl)-2- (trifluoromethoxy)phenyl)pyrazin- 2-yl)nicotinamide

24.

N-(5-(2-chloro-5-(3-fluoropyridin- 4-yl)phenyl)pyrazin-2-yl)-4- methylnicotinamide

26.

N-(5-(2-chloro-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)- 5-fluoro-4-methylnicotinamide

27.

N-(5-(2-ethyl-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)- 5-fluoro-4-methylnicotinamide

34.

N-(5-(2-chloro-5-((6- (trifluoromethyl)pyridin-2- yl)oxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide

36.

N-(5-(5-((3-fluoropyridin-2- yl)oxy)-2-methylphenyl)pyrazin- 2-yl)-4-methylnicotinamide

38.

N-(5-(5-((3-fluoropyridin-2-yl)oxy)-2- (trifluoromethoxy)phenyl)pyrazin- 2-yl)-4-methylnicotinamide

39.

N-(5-(2-cyano-5-(oxetan-3- yloxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide

44.

4-methyl-N-(5-(2-methyl-5-(pyridin- 3-ylethynyl)phenyl)pyrazin-2- yl)nicotinamide

45.

4-methyl-N-(5-(2-methyl-5-(2-methyl- 2H-tetrazol-5-yl)phenyl)pyrazin- 2-yl)nicotinamide

49.

N-(5-(2-chloro-5-(pyridin-2- yloxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide

50.

4-methyl-N-(5-(6- methylbenzo[d][1,3]dioxol-5- yl)pyrazin-2-yl)nicotinamide

51.

4-methyl-N-(5-(5-(pyridin-2-yloxy)-2- (trifluoromethoxy)phenyl)pyrazin- 2-yl)nicotinamide

52.

4-methyl-N-(5-(2-methyl-5-(1-methyl- 1 H-pyrazol-4-yl)phenyl)pyrazin-2- yl)nicotinamide

53.

N-(5-(2-chloro-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide

54.

N-(5-(2-chloro-5-(pyridin-2- yloxy)phenyl)pyrazin-2-yl)-5- fluoro-4-methylnicotinamide

56.

N-(5-(2-ethyl-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide

57.

N-(5-(2-chloro-5-(2-methyl-2H- tetrazol-5-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide

61.

N-(5-(2,5-dimethoxy- 1 H- benzo[d]imidazol-1-yl)pyrazin-2- yl)-4-methylnicotinamide

62.

N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2- yl)-4-methylnicotinamide

65.

N-(5-(5-methoxy-2-(trifluoromethyl)- 1 H-benzo[d]imidazol-1-yl)pyrazin-2- yl)-4-methylnicotinamide

66.

N-(5-(5-cyclopropoxy-2- methylphenyl)pyrazin-2-yl)-4- methylnicotinamide

68.

4-methyl-3-(5-(4- methylnicotinamido)pyrazin-2- yl)phenyl dimethylsulfamate

69.

4-methyl-3-(5-(4- methylnicotinamido)pyrazin-2- yl)phenyl methanesulfonate

79.

N-(5-(5-cyclopropoxy-2- methylphenyl)pyrazin-2-yl)-5- fluoro-4-methylnicotinamide

80.

N-(5-(2-chloro-5-(1,5-dimethyl- 1 H-pyrazol-4-yl)phenyl)pyrazin-2- yl)-4-methylnicotinamide

81.

5-bromo-N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2- yl)-4-methylnicotinamide

85.

N-(5-(2-chloro-5-((3-fluoropyridin-2- yl)oxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide

86.

N-(5-(2-cyclopropoxy-5-(1-methyl- 1 H-pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide

87.

N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2-yl)-4- methylnicotinamide hydrochloride

93.

4-chloro-3-(5-(4- methylnicotinamido)pyrazin-2- yl)phenyl methanesulfonate

101.

4-methyl-N-(5-(2-methyl-5-(1-methyl- 1 H-pyrazol-3-yl)phenyl)pyrazin-2- yl)nicotinamide

110.

N-(5-(2-methoxy-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide

114.

5-chloro-N-(5-(2-chloro-5-(1-methyl- 1 H-pyrazol-4-yl)phenyl)pyrazin-2- yl)-4-methylnicotinamide

121.

5-bromo-N-(5-(2-chloro-5-(1-methyl- 1 H-pyrazol-4-yl)phenyl)pyrazin-2- yl)-4-methylnicotinamide

123.

N-(5-(2-chloro-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 5-fluoro-4-methylnicotinamide

124.

4-methyl-N-(5-(2-methyl-5-(2- methylthiazol-4-yl)phenyl)pyrazin-2- yl)nicotinamide

129.

N-(5-(2-chloro-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4,5-dimethylnicotinamide

131.

N-(5-(2-chloro-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 5-ethyl-4-methylnicotinamide

132.

N-(5-(2-chloro-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 5-cyano-4-methylnicotinamide

137.

N-(5-(2-ethyl-5-((5-methylisoxazol-3- yl)oxy)phenyl)pyrazin-2-yl)-4- methylnicotinamide

142.

N-(5-(2-chloro-5-(1-methyl- 1 H- pyrazol-4-yl)phenyl)pyrazin-2-yl)- 4-methylnicotinamide hydrochloride

143.

5-fluoro-N-(5-(5-((3-fluoropyridin-2- yl)oxy)-2-methylphenyl)pyrazin-2-yl)- 4-methylnicotinamide

144.

N-(5-(2-chloro-5- isopropoxyphenyl)pyrazin-2-yl)-4- methylnicotinamide

196

N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2-yl)-4- methylnicotinamide hydrochloride

198

N-(5-(2-chloro-5-(oxetan-3- yloxy)phenyl)pyrazin-2-yl)-5- fIuoro-4-methylnicotinamide

200

N-(5-(2-chloro-5- cyclobutoxyphenyl)pyrazin-2-yl)- 5-fluoro-4-methylnicotinamide

201

5-chloro-N-(5-(5-cyclopropoxy-2- methylphenyl)pyrazin-2-yl)-4- methylnicotinamide

202

N-(5-(2-chloro-5- (cyclohexyloxy)phenyl)pyrazin-2- yl)-5-fluoro-4-methylnicotinamide

203

N-(5-(2-cyano-5- cyclopropoxyphenyl)pyrazin-2- yl)-5-fluoro-4-methylnicotinamide

204

N-(5-(2-chloro-5- (cyclopropylmethoxy)phenyl)pyrazin- 2-yl)-4-methylnicotinamide

205

N-(5-(2-cyano-5- cyclopropoxyphenyl)pyrazin-2- yl)-4-methylnicotinamide

206

N-(5-(2-chloro-5- (cyclopentyloxy)phenyl)pyrazin-2- yl)-4-methylnicotinamide

207

N-(5-(2-chloro-5- cyclopropoxyphenyl)pyrazin-2- yl)-5-fluoro-4-methylnicotinamide

208

N-(5-(5-cyclopropoxy-2- ethylphenyl)pyrazin-2-yl)-5- fluoro-4-methylnicotinamide

209

N-(5-(5-cyclopropoxy-2- ethylphenyl)pyrazin-2-yl)-4- methylnicotinamide

212

N-(5-(2-chloro-5- isopropoxyphenyl)pyrazin-2-yl)-4- methylnicotinamide

224

5-fluoro-4-methyl-N-(5-(2-methyl-5-((5- methylthiazol-2-yl)oxy)phenyl)pyrazin- 2-yl)nicotinamide

227

4-methyl-N-(5-(2-methyl-5-((3-methyl- 1,2,4-thiadiazol-5-yl)oxy)phenyl)pyrazin- 2-yl)nicotinamide

228

5-fluoro-4-methyl-N-(5-(2-methyl-5- ((3-methyl-1,2,4-thiadiazol-5- yl)oxy)phenyl)pyrazin-2-yl)nicotinamide

230

N-(5-(2-chloro-5- (trifluoromethoxy)phenyl)pyrazin- 2-yl)-4-methylnicotinamide

231

N-(5-(2-ethyl-5- (trifluoromethoxy)phenyl)pyrazin- 2-yl)-4-methylnicotinamide

240

5-fluoro-4-methyl-N-(5-(2-methyl- 5-(pyrimidin-2-yloxy)phenyl)pyrazin- 2-yl)nicotinamide

And

242

N-(5-(2-chloro-5-(pyrimidin-2- yloxy)phenyl)pyrazin-2-yl)-5- fluoro-4-methylnicotinamide

or a pharmaceutically acceptable salt, or solvate thereof.

2. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt or solvate thereof and a pharmaceutically acceptable excipient.

3. The compound of claim 1 of the formula:

or a pharmaceutically acceptable salt, or solvate thereof.

4. The compound of claim 1 of the formula:

or a pharmaceutically acceptable salt, or solvate thereof.

5. The compound of claim 1 of the formula:

or a pharmaceutically acceptable salt, or solvate thereof.

6. The compound of claim 1 of the formula:

or a pharmaceutically acceptable salt, or solvate thereof.

7. The compound of claim 1 of the formula:

or a pharmaceutically acceptable salt, or solvate thereof.

8. The compound of claim 1 of the formula:

or a pharmaceutically acceptable salt, or solvate thereof.

9. The compound of claim 1 of the formula:

or a pharmaceutically acceptable salt, or solvate thereof.