IP Library › Granted Patent US 9,618,513
Granted Patent B2
US 9,618,513 · App. 14/605,519 · Granted Apr 11, 2017

Compositions and methods for detecting and treating colorectal cancer

Inventors: Weiping Zou (Ann Arbor, MI); Ilona Kryczek (Ann Arbor, MI)
Assignee: The Regents of the University of Michigan
G01N33/57419A61K31/7076A61K31/713A61K31/7105A61K45/06C07K16/244C12N15/1136C12N15/1137C12Q1/6886C12Y201/01043C07K2317/76C12N2310/14C12N2310/531C12Q2600/158G01N2333/4706G01N2333/54G01N2333/91017
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Quick Facts
Patent No.
US 9,618,513
App. No.
14/605,519
Granted
Apr 11, 2017
Kind
B2
Abstract

The present invention relates to compositions and methods for the detecting, treating, and empirically investigating the interaction between a subject's immune system and cancer stem cells. In particular, the present invention provides compositions and methods for using IL-22 cytokine signaling and/or downstream targets of IL-22 cytokine signaling (e.g., STAT3, DOT1L, SUZ12, EED) in the diagnosis, treatment, and empirical investigation of cancers characterized with cancer stem cells activated through IL-22 cytokine signaling.

Claims (4)

1. A method of treating colorectal cancer characterized with activated cancer stem cells in a subject, the method comprising

administering to said subject an agent that down regulates the expression, amount or activity of DOT1L, wherein said administering inhibits cancer stem cell activation within colorectal cancer cells,

wherein the agent is a DOT1L inhibiting agent, wherein the DOT1L inhibiting agent is

a pharmaceutical composition comprising EPZ5676.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 23, 2015
From: UNIVERSITY OF MICHIGAN
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 036013/0068 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 27, 2015
From: ZOU, WEIPING; KRYCZEK, ILONA
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Reel/Frame 034817/0491 →
Continuity (2)
Provisional Application 61931891 · Jan 27, 2014
Related Publication 20150212088A1 · Jul 30, 2015