IP Library › Granted Patent US 9,637,740
Granted Patent B2
US 9,637,740 · App. 14/390,265 · Granted May 2, 2017

Cancer treatment and immune system regulation through FAT10 pathway inhibition

Inventors: Yifat Merbl (Boston, MA); Marc W. Kirschner (Newton, MA)
Assignee: President and Fellows of Harvard College
C12N15/113A01K67/0276A61K31/713A61K31/7105C07K14/00G01N33/5011G01N33/68A01K2217/075A01K2227/105A01K2267/0331C12N2310/11C12N2310/14C12N2320/30G01N2333/70539G01N2500/02G01N2800/24G01N2800/7028
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Quick Facts
Patent No.
US 9,637,740
App. No.
14/390,265
Granted
May 2, 2017
Kind
B2
Abstract

Described herein are methods of inhibiting mitosis, treating cancer and/or treating immune disorders through the use of agents that inhibit FAT 10 and/or the FAT 10 pathway.

Claims (7)

1. A method of treating type I diabetes in a subject comprising administering to the subject an inhibitory nucleic acid specific for an mRNA that encodes FAT10.

2. The method of claim 1 , wherein the inhibitory nucleic acid is of an siRNA.

3. The method of claim 1 , wherein the inhibitory nucleic acid is an shRNA.

4. The method of claim 1 , wherein the inhibitory nucleic acid is an antisense RNA molecule.

5. The method of claim 1 , wherein the inhibitory nucleic acid is a nucleic acid that encodes an siRNA.

6. The method of claim 1 , wherein the inhibitory nucleic acid is a nucleic acid that encodes an shRNA.

7. The method of claim 1 , wherein the inhibitory nucleic acid is a nucleic acid that encodes and antisense RNA molecule.

Assignments (1)
CONFIRMATORY LICENSE Recorded Sep 18, 2018
From: HARVARD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 047101/0660 →
Continuity (2)
Provisional Application 61619091 · Apr 2, 2012
Related Publication 20150322427A1 · Nov 12, 2015