Dose measurement system and method
Embodiments described herein generally relate to devices, systems and methods for measuring the dose remaining in a drug delivery device that is used for delivering a dose to a patient. In some embodiments, a dose measurement system for measuring the liquid volume in a container includes a plurality of light sources which are disposed and configured to emit electromagnetic radiation toward the container. A plurality of sensors are located in the apparatus that are optically coupleable to the plurality of light sources and are disposed and configured to detect the electromagnetic radiation emitted by at least a portion of the light sources. The apparatus also includes a processing unit configured to receive data representing the portion of the detected electromagnetic radiation from each of the plurality of sensors. The processing unit is further operable to convert the received data into a signature representative of the electromagnetic radiation detected by the plurality of sensors.
1. A method of estimating a volume of liquid in a drug container, the method comprising:
causing a plurality of light sources to emit electromagnetic radiation toward the drug container;
detecting the electromagnetic radiation emitted by at least two of the plurality of light sources;
generating a signal signature representative of the detected electromagnetic radiation; and
comparing the signal signature to a plurality of reference signatures to determine the volume of liquid in the drug container.
2. The method of claim 1 , further comprising:
calculating a dose delivered to a patient based on the volume of liquid in the drug container.
3. A method, comprising:
causing a plurality of light sources to emit electromagnetic radiation toward an injection pen a first time;
detecting the electromagnetic radiation emitted by at least two of the plurality of light sources with a plurality of sensors at the first time;
generating a first signal signature representative of the detected electromagnetic radiation;
comparing the first signal signature to a plurality of reference signatures to determine a first volume of liquid in the injection pen;
causing the plurality of light sources to emit electromagnetic radiation toward the injection pen a second time after the first time;
detecting the electromagnetic radiation emitted by at least two of the plurality of light sources with the plurality of sensors at the second time generating a second signal signature representative of the detected electromagnetic radiation;
comparing the second signal signature to the plurality of reference signatures to determine a second volume of liquid in the injection pen; and
estimating a dose delivered from the injection pen based on the first volume and the second volume.
4. The method of claim 3 , wherein the plurality of light sources and the plurality of sensors are disposed in an injection pen cap, the method further comprising:
detecting the first signal signature prior to the injection pen cap being removed from the injection pen; and
detecting the second signal signature after the injection pen cap has been placed back on the injection pen.
5. The method of claim 1 , further comprising:
correcting the signal signature for background light.
6. The method of claim 5 , wherein correcting the signal signature for background light includes comparing the signal signature with a background signature in a dark state of each of the plurality of light sources.
7. The method of claim 1 , further comprising:
communicating information associated with the volume of liquid in the drug container to an external device.
8. The method of claim 1 , further comprising:
generating the plurality of reference signatures by recording a signal signature for each of a range of dose volumes in the drug container.
9. The method of claim 1 , wherein the drug container is at least part of a drug delivery device, the method further comprising:
determining, based at least in part on the plurality of reference signatures, at least one of: a coupling or a decoupling of the plurality of light sources to the drug delivery device; an attachment or a detachment of an injector to the drug delivery device; a property of the drug delivery device; and a property of a liquid disposed in the drug container.
10. The method of claim 9 , wherein the drug delivery device is an injection pen, the method further comprising:
determining, based at least in part on the plurality of reference signatures, at least one of: an attachment or a detachment of a needle to the injection pen; and a property of the injection pen.
11. The method of claim 3 , further comprising:
communicating information associated with the dose delivered to an external device.
12. The method of claim 3 , further comprising:
generating the plurality of reference signatures by recording a signal signature for each of a range of dose volumes in the injection pen.
13. The method of claim 3 , wherein the plurality of light sources and the plurality of sensors are disposed in an injection pen cap removably coupleable to the injection pen.
14. A method of estimating a volume of liquid in a drug container, the method comprising:
causing a plurality of light sources to emit electromagnetic radiation toward the drug container;
detecting the electromagnetic radiation emitted by at least two of the plurality of light sources;
generating a signal signature representative of the detected electromagnetic radiation; and
comparing the signal signature to a plurality of reference signatures to determine the a property of the drug container.
15. The method of claim 14 , wherein the property of the drug container includes a property of a fluid disposed in the drug container.
16. The method of claim 14 , wherein the property of the drug container includes at least one of a refractive index, a color, a marking, and a label.
17. The method of claim 14 , further comprising:
generating the plurality of reference signatures by recording a signal signature for each of a plurality of container types.
18. The method of claim 14 , wherein the property of the drug container indicates a container type.
19. The method of claim 14 , further comprising:
correcting the signal signature for background light.
20. The method of claim 19 , wherein correcting the signal signature for background light includes comparing the signal signature with a background signature in a dark state of each of the plurality of light sources.