Method for diagnosing a rhinovirus infection
The present invention relates to a pharmaceutical composition comprising at least one peptide consisting of a minimum of 8 and a maximum of 50 amino acid residues comprising amino acid residues 1 to 8 of a rhinovirus capsid protein selected from the group consisting of VP1, VP2, VP3 and VP4.
1. A method for diagnosing in vitro a rhinovirus infection caused by at least one of rhinovirus strains 1B, 29, 47, 62, 79 and 89 in a mammal comprising the steps of:
providing an antibody comprising sample of a mammal,
contacting said sample with at least one peptide consisting of a minimum of 15 and a maximum of 50 amino acid residues comprising amino acid residues 1 to 15 of a rhinovirus VP1 capsid protein of rhinovirus strain 89, and
diagnosing a rhinovirus infection when the binding of antibodies to said at least one peptide is detected.
2. The method according to claim 1 , characterized in that the sample is a blood sample, a sputum sample, neural lavage fluid sample or tear sample.
3. The method according to claim 1 , characterised in that the amino acid residues 1 to 15 of the rhinovirus capsid protein have amino acid sequence NPVENYIDSVLNEVL (amino acids 1-15 of SEQ ID NO:49).
4. The method according to claim 1 , characterised in that the at least one peptide is selected from the group consisting of NPVENYIDSVLNEVLVVPNIQPSTSVSSHAA (SEQ ID NO:48) and NPVENYIDSVLNEVLVVPNIQ (SEQ ID NO:49).
5. The method according to claim 2 , wherein the blood sample is serum or plasma.