IP Library › Granted Patent US 9,662,312
Granted Patent B2
US 9,662,312 · App. 14/631,768 · Granted May 30, 2017

Method for treating glomerulosclerosis

Inventors: Jinkun Zhang (San Diego, CA); Zofia E. Dziewanowska (La Jolla, CA); Rene Belder (Hopewell, NJ); Ian Henderson (San Diego, CA); Joseph B. Bogardus (Keene, NY); Zhaoying Zhang (Monmouth Junction, NJ)
Assignee: Ligand Pharmaceuticals Inc.
A61K31/422A61K9/2013A61K9/2018A61K9/2031A61K9/2054A61K9/2059C07D413/12
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Quick Facts
Patent No.
US 9,662,312
App. No.
14/631,768
Granted
May 30, 2017
Kind
B2
Abstract

Methods of administering and pharmaceutical compositions of a biphenyl sulfonamide compound which is a dual angiotensin and endothelin receptor antagonist are disclosed for treating diseases.

Claims (5)

1. A method of treating glomerulosclerosis comprising administering to a subject in need thereof an effective amount of a compound of Formula I:

or a pharmaceutically acceptable salt thereof, wherein the amount of the compound of Formula I, or pharmaceutically acceptable salt thereof, administered to the subject is 200 mg/day, 400 mg/day, or 800 mg/day.

2. The method according to claim 1 , wherein the amount of the compound of Formula I, or pharmaceutically acceptable salt thereof, administered to the subject is 200 mg/day.

3. The method according to claim 1 , wherein the amount of the compound of Formula I, or pharmaceutically acceptable salt thereof, administered to the subject is 400 mg/day.

4. The method according to claim 1 , wherein the amount of the compound of Formula I, or pharmaceutically acceptable salt, administered to the subject is 800 mg/day.

Assignments (2)
SECURITY INTEREST Recorded Oct 18, 2023
From: CYDEX PHARMACEUTICALS, INC.; LIGAND PHARMACEUTICALS INCORPORATED; METABASIS THERAPEUTICS, INC.; PFENEX INC.
To: CITIBANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 065271/0025 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 15, 2016
From: ZHANG, JINKUN; DZIEWANOWSKA, ZOFIA E.; BELDER, RENE; HENDERSON, IAN; BOGARDUS, JOSEPH B.; ZHANG, ZHAOYING
To: LIGAND PHARMACEUTICALS INC.
Reel/Frame 039168/0520 →
Continuity (6)
Continuation 13720452 · Dec 19, 2012
Continuation 13471364 · May 14, 2012
Continuation 13262223
Provisional Application 61165419 · Mar 31, 2009
Provisional Application 61165447 · Mar 31, 2009
Related Publication 20150164865A1 · Jun 18, 2015