Fluoride composition and methods for dental mineralization
The present invention relates to compositions and methods for mineralizing a dental surface or subsurface including providing a composition including stabilized ACP and a source of fluoride ions.
1. A method of mineralizing a dental surface or subsurface comprising providing a composition to contact the dental surface or subsurface, wherein the composition, prior to contacting the dental surface or subsurface, comprises (i) about 2% by weight casein phosphopeptide-stabilized amorphous calcium phosphate or casein phosphopeptide-stabilized amorphous calcium fluoride phosphate, and, separately, (ii) free fluoride ions in an amount of from at least 400 ppm to about 3,000 ppm.
2. A method according to claim 1 , wherein the composition is selected from the group consisting of toothpaste; tooth gel; tooth powder; dental creme; liquid dentifrice; mouthwash; troche; chewing gum; gingival massage creme; gargle tablet and dental restorative.
3. A method according to claim 1 , wherein the composition comprises sodium fluoride.
4. A method for remineralizing a subsurface enamel lesion comprising providing a composition to contact the subsurface enamel lesion, wherein the composition, prior to contacting the subsurface enamel lesion, comprises (i) about 2% by weight casein phosphopeptide-stabilized amorphous calcium phosphate or casein phosphopeptide-stabilized amorphous calcium fluoride phosphate, and, separately, (ii) free fluoride ions in an amount of from at least 400 ppm to about 3,000 ppm.
5. A method according to claim 4 , wherein the composition is selected from the groups consisting of toothpaste; tooth gel; tooth powder; dental creme; liquid dentifrice; mouthwash; troche; chewing gum; gingival massage creme; gargle tablet and dental restorative.
6. A method of treating and/or preventing dental caries in tooth enamel comprising providing a composition to contact the tooth enamel, wherein the composition, prior to contacting the tooth enamel, comprises (i) about 2% by weight casein phosphopeptide-stabilized amorphous calcium phosphate or casein phosphopeptide-stabilized amorphous calcium fluoride phosphate, and, separately, (ii) free fluoride ions in an amount of from at least 400 ppm to about 3,000 ppm.
7. A method of increasing fluoride uptake into a dental surface or subsurface from an oral composition, the method comprising incorporating about 2% by weight casein phosphopeptide-stabilized amorphous calcium phosphate or casein phosphopeptide-stabilized amorphous calcium fluoride phosphate into the oral composition prior to treatment of the dental surface or subsurface, wherein the oral composition separately comprises free fluoride ions in an amount of from at least 400 ppm to about 3,000 ppm.
8. A method of increasing the dental remineralization efficacy of an oral composition, the method comprising incorporating about 2% by weight casein phosphopeptide-stabilized amorphous calcium phosphate or casein phosphopeptide-stabilized amorphous calcium fluoride phosphate into the oral composition prior to treatment of the dental surface or subsurface, wherein the oral composition separately comprises free fluoride ions in an amount of from at least 400 ppm to about 3,000 ppm.
9. A method of increasing fluoride uptake into a dental surface or subsurface from an oral composition, the method comprising incorporating about 2% by weight casein phosphopeptide-stabilized amorphous calcium phosphate or casein phosphopeptide-stabilized amorphous calcium fluoride phosphate into the oral composition prior to treatment of the plaque, wherein the oral composition separately comprises free fluoride ions in an amount of from at least 400 ppm to about 3,000 ppm.
10. A method according to claim 1 , wherein the dental surface or subsurface is tooth enamel.
11. A method according to claim 1 , wherein the dental subsurface is a subsurface enamel lesion.
12. A method according to claim 4 , wherein the composition comprises sodium fluoride.
13. A method of mineralizing a dental surface or subsurface according to claim 3 , wherein the composition further comprises a dentally acceptable polishing material and a surfactant prior to contacting the dental surface or subsurface, wherein the composition does not contain a calcium chelator or a phosphate buffer.
14. A method of increasing the dental remineralization efficacy of an oral composition containing about 2% by weight casein phosphopeptide-stabilized amorphous calcium phosphate or casein phosphopeptide-stabilized amorphous calcium fluoride phosphate, the method comprising separately incorporating free fluoride ions in an amount of from at least 400 ppm to about 3,000 ppm free fluoride ions into the oral composition prior to treatment of a dental surface or subsurface.
15. A method for manufacturing a composition for mineralizing a dental surface or subsurface comprising preparing a composition comprising (i) about 2% by weight casein phosphopeptide-stabilized amorphous calcium phosphate or casein phosphopeptide-stabilized amorphous calcium fluoride phosphate, and, separately, (ii) free fluoride ions in an amount of from at least 400 ppm to about 3,000 ppm.
16. The method according to claim 15 , wherein the composition comprises sodium fluoride.
17. The method according to claim 6 , wherein the composition comprises sodium fluoride.
18. The method according to claim 14 , wherein the composition comprises sodium fluoride.
19. A method according to claim 1 , wherein the free fluoride ions are provided by sodium fluoride, stannous fluoride, amine fluoride and combinations thereof.
20. A method according to claim 1 , wherein the composition comprises free fluoride ions in a range of about 400 ppm to 1500 ppm.
21. A method according to claim 1 , wherein the composition comprises about 900 ppm free fluoride.
22. A method according to claim 4 , wherein the composition comprises free fluoride ions in a range of about 400 ppm to 1500 ppm.
23. A method according to claim 4 , wherein the composition comprises about 900 ppm free fluoride.
24. A method according to claim 6 , wherein the composition comprises free fluoride ions in a range of about 400 ppm to 1500 ppm.
25. A method according to claim 6 , wherein the composition comprises about 900 ppm free fluoride.