Method of treatment for enhancing exercise performance
Provided is a composition containing myricetin or a pharmaceutically available salt thereof as an active ingredient. The composition increases exercise capacity and enhances physical strength. In addition, the composition prevents aging and recovers from fatigue. The composition increases energy efficiency by improving the function of mitochondria, and also has an antiobesity effect by increasing energy consumption. Therefore, the composition may be significantly applied in a functional food or medicine field.
1. A method of treatment for enhancing exercise capacity, the method comprising:
orally administering, to a subject in need of such treatment, an effective amount of myricetin or a pharmaceutically acceptable salt thereof; and
subsequently estimating expression by PCR of a peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1 α), nuclear respiratory factor-1 (NRF-1), or peroxisome proliferator-activated receptor-δ (PPAR-δ) gene or sirtuin-1 (SIRT-1) gene.
2. The method of claim 1 , wherein the oral administration is repeated for an extended period.
3. The method of claim 2 , wherein the extended period is at least 2 weeks.
4. The method of claim 2 , wherein the effective amount per day is from 0.01 to 100 mg for 1 kg of the subject's weight.
5. The method of claim 2 , wherein the effective amount per day is 50 mg for 1 kg of the subject's weight.