IP Library Granted Patent US 9,675,649
Granted Patent B2
US 9,675,649 · App. 13/983,624 · Granted Jun 13, 2017

Disialyllacto-N-tetraose (DSLNT) or variants, isomers, analogs and derivatives thereof to prevent or inhibit bowel disease

Inventor: Lars Bode (San Diego, CA)
Assignee: The Regents of the University of California
A61K35/742A23K10/18A23K20/163A23K40/10A23K50/00A23L29/30A23L33/135A23L33/40A23P10/28A61K31/702A61K35/741G01N33/50G01N2400/00G01N2800/065G01N2800/067G01N2800/38G01N2800/7095
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Quick Facts
Patent No.
US 9,675,649
App. No.
13/983,624
Granted
Jun 13, 2017
Kind
B2
Abstract

The invention provides formulations comprising isolated Disialyllacto-N-tetraose (DSLNT) or variants, isomers, analogs and derivatives thereof.

Claims (6)

1. An infant formula or baby food comprising a formulation that is substantially free of non-disialyllacto-N-tetraose (DSLNT) oligosaccharides, which comprises a pharmaceutically acceptable carrier and an isolated compound selected from the group consisting of α-Neu5Ac-(2→3)-α-Gal-(1→3)-[α-Neu5Ac-(2→6)]-β-GlcNAc-(1→3)-β-Gal-(1→4)-Glc, α-Neu5Ac-(2→3)-β-Gal-(1→3)-[α-Neu5Ac-(2→6)]-α-GlcNAc-(1→3)-β-Gal-(1→4)-Glc, α-Neu5Ac-(2→3)-β-Gal-(1→3)-[α-Neu5Ac-(2→6)]-β-GlcNAc-(1→3)-β-Gal-(1→4)-Glc, β-Neu5Ac-(2→3)-β-Gal-(1→3)-[α-Neu5Ac-(2→6)]-β-GlcNAc-(1→3)-β-Gal-(1→4)-Glc, and α-Neu5Ac-(2→3)-β-Gal-(1→3)-[β-Neu5Ac-(2→6)]-β-GlcNAc-(1→3)-β-Gal-(1→4)-Glc,

wherein the formulation comprises at least 800 μM or greater of the compound.

2. The infant formula or baby food of claim 1 , which is a liquid, a gel, or a solid.

3. The infant formula or baby food of claim 1 , wherein the formulation additionally comprises a probiotic.

4. The infant formula or baby food of claim 3 , wherein the probiotic comprises bacterial species from the genera Bifidobacteria and/or Lactobacilli.

5. The infant formula of claim 1 further comprising a vitamin and/or mineral.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 16, 2015
From: BODE, LARS
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 036813/0015 →
CONFIRMATORY LICENSE Recorded Sep 11, 2013
From: UNIVERSITY OF CALIFORNIA SAN DIEGO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031203/0379 →
Continuity (2)
Provisional Application 61439705 · Feb 4, 2011
Related Publication 20130315990A1 · Nov 28, 2013