IP Library › Granted Patent US 9,676,794
Granted Patent B2
US 9,676,794 · App. 15/351,843 · Granted Jun 13, 2017

Benzodiazepine dimers, conjugates thereof, and methods of making and using

Inventors: Yong Zhang (West Windsor, NJ); Ivar M. McDonald (East Haddam, CT); Naidu S. Chowdari (Sunnyvale, CA); Tram N. Huynh (Pennington, NJ); Robert M. Borzilleri (Carversville, PA); Sanjeev Gangwar (Foster City, CA)
Assignee: Bristol-Myers Squibb Company
C07D519/00
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Quick Facts
Patent No.
US 9,676,794
App. No.
15/351,843
Granted
Jun 13, 2017
Kind
B2
Abstract

Benzodiazepine dimers having a structure represented by wherein R 1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

Claims (1)

1. A compound having a structure represented by formula (IIa-01):

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 16, 2017
From: ZHANG, YONG; MCDONALD, IVAR M.; CHOWDARI, NAIDU S.; HUYNH, TRAM N.; BORZILLERI, ROBERT M.; GANGWAR, SANJEEV
To: BRISTOL-MYERS SQUIBB COMPANY
Reel/Frame 041273/0502 →
Continuity (4)
Continuation 14994296 · Jan 13, 2016
Provisional Application 62103157 · Jan 14, 2015
Provisional Application 62215928 · Sep 9, 2015
Related Publication 20170073357A1 · Mar 16, 2017