Anti-properdin antibodies
A method of inhibiting alternative complement pathway activation in a mammal includes administering an amount of an antibody and/or fragment thereof that specifically binds to an epitope of the N terminus end of properdin effective to the inhibit alternative complement pathway in the subject.
1. An isolated anti-properdin antibody or antigen binding fragment thereof that specifically binds to the amino acid sequence of SEQ ID NO: 2 of properdin.
2. The isolated anti-properdin antibody or antigen binding fragment thereof of claim 1 , wherein the anti-properdin antibody is a monoclonal antibody.
3. A composition comprising:
an isolated anti-properdin antibody or antigen binding fragment thereof that specifically binds to the amino acid sequence of SEQ ID NO: 2 of properdin, and a pharmaceutically acceptable carrier.
4. The pharmaceutical composition of claim 3 , wherein the anti-properdin antibody is a monoclonal antibody.