Systems for detecting a condition
The invention generally relates to systems for measuring impedance change in order to detect a condition. In certain aspects, the invention provides systems for monitoring tissue and detecting a condition that include at least one energy source, a transduction unit, and a pattern recognition component that compares impedance signatures recorded from the transduction unit with a database of impedance signatures associated with medical conditions.
1. A system for monitoring tissue and detecting a condition, the system comprising:
at least one energy source configured to output to a tissue an energy field comprising a fixed energy component at a pre-determined frequency;
a transduction unit configured to:
receive a signal from the tissue over multiple time points;
generate a first impedance value at a first time point by determining a correlation at the first time point between the output of the fixed energy component at the pre-determined frequency and the received signal from the tissue at the first time point;
generate a second impedance value at a second time point by determining a correlation at the second time point between the output of the fixed energy component at the pre-determined frequency and the received signal from the tissue at the second time point; and
generate an impedance signature that is representative of a change in the first impedance value at the first time point and the second impedance value at the second time point; and
a pattern recognition component that compares the impedance signature generated by the transduction unit with a database of one or more impedance signatures of a traumatic brain injury.
2. The system according to claim 1 , wherein the energy source is an electric source that produces an electric field.
3. The system according to claim 2 , wherein the electric field is pulsed.
4. The system according to claim 2 , wherein the electric field is time varying.
5. The system according to claim 2 , wherein the electric field is pulsed a plurality of time, and each pulse may be for a different length of time.
6. The system according to claim 2 , wherein the electric field is time invariant.
7. The system according to claim 2 , wherein the electric source is at least one electrode.
8. The system according to claim 1 , wherein the energy source and the transduction unit are integrated with each other.
9. The system according to claim 7 , wherein the electrode may be a component of a second system selected from the group consisting of: EEG, EKG, EOG, ERG, and ENG.
10. The system according to claim 1 , wherein the system is integrated with an imaging system.
11. The system according to claim 1 , wherein the energy source is selected from the group consisting of: electromagnetic, chemical, optical, thermal, mechanical, and a combination thereof.
12. The system according to claim 11 , wherein the mechanical field is generated by an ultrasound device.
13. A system for monitoring tissue and detecting a condition, the system comprising:
an electric source that produces an electric field at a fixed current a pre-determined frequency;
an electrical transduction unit configured to:
receive a signal from the tissue over multiple time points;
generate a first impedance value at a first time point by determining a correlation at the first time point between the electric field at the fixed current the pre-determined frequency and the received signal from the tissue at the first time point;
generate a second impedance value at a second time point by determining a correlation at the second time point between the electric field at the fixed current the pre-determined frequency and the received signal from the tissue at the second time point; and
generate an impedance signature that is representative of a change in the first impedance value at the first time point and the second impedance value at the second time point; and;
a pattern recognition component that compares the impedance signature generated by the transduction unit with a database of one or more impedance signatures of a traumatic brain injury; and
a helmet that houses at least the electric source or transduction unit.
14. The system according to claim 13 , wherein the electrical transduction unit measures the electrical impedance of the tissue.
15. The system according to claim 13 , wherein the system is integrated with a second system selected from the group consisting of: EEG, EKG, EOG, ERG, and ENG.
16. A system for monitoring tissue and detecting a condition, the system comprising:
a noninvasive transcranial stimulator configured to output to a tissue an energy field comprising a fixed energy component at a pre-determined frequency;
a transduction unit configured to:
receive a signal from the tissue over multiple time points;
generate a first impedance value at a first time point by determining a correlation at the first time point between the output of the fixed energy component at the pre-determined frequency and the received signal from the tissue at the first time point;
generate a second impedance value at a second time point by determining a correlation at the second time point between the output of the fixed energy component at the pre-determined frequency and the received signal from the tissue at the second time point; and
generate an impedance signature that is representative of a change in the first impedance value at the first time point and the second impedance value at the second time point; and
a pattern recognition component that compares the impedance signature generated by the transduction unit with a database of one or more impedance signatures of a traumatic brain injury.