Diamide compounds having muscarinic receptor antagonist and β
This invention relates to a compound of formula I: or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic receptor antagonist and β 2 adrenergic receptor agonist activities. The invention also relates to pharmaceutical compositions comprising such compounds, processes and intermediates for preparing such compounds, and methods of using such compounds as bronchodilating agents to treat pulmonary disorders.
1. A compound of the formula:
wherein:
Y is a group of formula (a):
and Y is attached at the 3- or 4-position of the phenylene ring relative to the
group;
X is selected from —C(O)NH— and —NHC(O)—;
Ar 1 is selected from phen-1,3-ylene and phen-1,4-ylene, wherein the phenylene group is unsubstituted or substituted with 1 to 3 substituents selected independently from C 1-3 alkyl, —O—(C 1-3 alkyl) and halo;
R 1 is selected independently from C 1-3 alkyl, —O—(C 1-3 alkyl), hydroxyl and halo;
R 2 is selected independently from C 1-3 alkyl, —O—(C 1-3 alkyl) and halo;
R 3 is selected independently from C 1-3 alkyl; or two R 3 groups are joined to form C 1-3 alkylene, C 2-3 alkenylene or oxiran-2,3-diyl;
R 4 is selected independently from C 1-3 alkyl, —O—(C 1-3 alkyl) and halo;
R a is selected from C 1-6 alkyl;
a is 0, 1, 2 or 3;
b is 0, 1, 2 or 3;
c is 0, 1, 2, 3 or 4;
d is 0, 1, 2 or 3;
n is 0 or 1;
p is 0, 1, 2, 3, 4, 5 or 6; provided that when n is 0, p is 1, 2, 3, 4, 5 or 6;
q is 0, 1, 2, 3, 4, 5 or 6;
and
P 2a and P 2b are selected independently from C 1-6 alkyl, or P 2a and P 2b are joined to form C 2-6 alkylene.
2. The compound according to claim 1 , wherein P 2a and P 2b are joined to form C 2-4 alkylene.