Granted Patent
B2
US 9,683,000 · App. 15/017,329 · Granted Jun 20, 2017
Carbonate prodrugs and methods of using the same
Assignee:
Acorda Therapeutics, Inc.
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Abstract
The present invention provides carbonate prodrugs which comprise a carbonic phosphoric anhydride prodrug moiety attached to the hydroxyl or carboxyl group of a parent drug moiety. The prodrugs may provide improved physicochemical properties over the parent drug. Also provided are methods of treating a disease or condition that is responsive to the parent drug using the carbonate prodrugs, as well as kits and unit dosages.
Claims (2)
1. A compound of the formula
or a salt thereof.
Assignments (4)
RELEASE OF SECURITY INTEREST
Recorded May 31, 2017
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: NEURONEX, INC.; CIVITAS THERAPEUTICS, INC.; ACORDA THERAPEUTICS, INC.
Reel/Frame 042643/0878 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 12, 2017
From: MUHAMMAD, NAWEED; BLEY, KEITH R.
To: NEUROGESX, INC.
Reel/Frame 040973/0563 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 12, 2017
From: NEUROGESX, INC.
To: ACORDA THERAPEUTICS, INC.
Reel/Frame 041355/0080 →
SECURITY INTEREST
Recorded Jun 10, 2016
From: ACORDA THERAPEUTICS, INC.; CIVITAS THERAPEUTICS, INC.; NEURONEX, INC.
To: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 038950/0436 →
Continuity (5)
Division
12993089
Provisional Application
61054765
· May 20, 2008