Treating mucosal lesions with hyaluronan delivered from an adhering troche
A troche comprising at least 5 mg hyaluronan, wherein the troche is adherent, and wherein hyaluronan is released from the troche, is used to treat mucositis, including stomatitis, vestibulitis, aphthous ulcerations, lichen planus and Behcet's syndrome. A method for treating or preventing mucositis in a patient is provided, comprising applying to a mucosal surface or a tooth or orthodontic brace of a patient in need thereof an adhering troche comprising at least 5 mg hyaluronan.
1. A bilayer troche comprising from 5 mg to 250 mg hyaluronan and a mucoadhesive other than hyaluronan, wherein the troche has an adherent layer and a non-adherent layer, wherein the non-adherent layer is a pressed powder that comprises hyaluronan and a lubricating substance, wherein the adherent layer is a pressed powder that comprises the mucoadhesive other than hyaluronan, and wherein, when held in a human mouth, hyaluronan is released from the troche, thereby treating mucositis.
2. The troche of claim 1 , wherein the troche comprises from 10 mg to 100 mg hyaluronan.
3. The troche of claim 1 , wherein the troche comprises from 2% to 50% hyaluronan.
4. The troche of claim 1 , wherein the hyaluronan has an average molecular weight of at least 500,000 daltons.
5. The troche of claim 1 , wherein the hyaluronan has an average molecular weight of at least 1,500,000 daltons.
6. A method for treating a mucositis in a patient applying the bilayer troche of claim 1 to a mucosal surface or a tooth or orthodontic brace of the patient in need thereof.
7. The method of claim 6 , wherein the hyaluronan has an average molecular weight of at least 500,000 daltons.
8. The method of claim 6 , wherein the hyaluronan has an average molecular weight of at least 1,500,000 daltons.
9. The method of claim 6 , wherein the adhering troche is applied just before sleeping.
10. The method of claim 6 , wherein the adhering troche is applied at least once a day every day for prevention.
11. The method of claim 6 , wherein the mucositis is stomatitis or aphthous ulcers.
12. The method of claim 6 , wherein the mucositis occurs in an oro-pharynx or an oesophagus.
13. The method of claim 6 , wherein the mucositis occurs in a vagina, vulva, or rectum.
14. The troche of claim 1 , wherein the non-adherent layer comprises no more than 50% hyaluronan.
15. The troche of claim 1 , wherein the lubricating substance is cellulose gum.
16. The troche of claim 1 , wherein the lubricating substance is magnesium stearate.