Controlled drug release liposome composition
View Patent ↗The present invention relates to a pharmaceutical composition comprising at least one liposome, at least one polyvalent counterion donor or a pharmaceutically acceptable salt thereof, at least one monovalent counterion donor or a pharmaceutically acceptable salt thereof, and an amphipathic therapeutic agent. The present invention also relates to methods of inhibiting cancer cell growth, comprising administering the pharmaceutical composition described herein.
1. A pharmaceutical composition, comprising:
at least one liposome having a particle forming component selected from a phospholipid or a mixture of at least one phospholipid and cholesterol;
0.1 mM to 3.0 mM dextran sulfate or a pharmaceutically acceptable salt thereof;
100 mM to 400 mM ammonium sulfate or a pharmaceutically acceptable salt thereof; and
vinorelbine.
2. The pharmaceutical composition of claim 1 , wherein the liposome further comprises a hydrophilic polymer with a long chain of highly hydrated flexible polymer attached to a phospholipid molecule.
3. The pharmaceutical composition of claim 1 , wherein dextran sulfate has a molecular weight about 1,600 daltons to about 8,000 daltons.