Compositions for topical treatment of microbial infections
The present invention provides compositions and methods for topical treatment of infections. The compositions comprise glycerol monolaurate or a derivative thereof, and are administered topically, for example, to treat viral, fungal or bacterial infections.
1. A composition comprising glycerol monolaurate, propylene glycol at a concentration of about 65% (w/w) to about 80% (w/w), polyethylene glycol at a concentration of about 20% (w/w) to about 35% (w/w), and a cellulose derivative.
2. The composition of claim 1 , further comprising a vegetable oil.
3. The composition of claim 2 , wherein the vegetable oil is palm oil, olive oil, com oil, canola oil, coconut oil, soybean oil, wheat germ oil, jojoba oil, castor oil, a combination thereof, a combination of olive oil and soybean oil, a combination of coconut oil and wheat germ oil, or a combination of jojoba oil, palm oil, and castor oil.
4. The composition of claim 1 , wherein the cellulose derivative is hydroxypropyl cellulose or hydroxyethyl cellulose.
5. The composition of claim 1 , wherein the cellulose derivative is present at a concentration of about 0.1% (w/w) to about 5.0% (w/w).
6. The composition of claim 1 , wherein the polyethylene glycol is in the molecular weight range of about 300 to about 600.
7. The composition of claim 1 , wherein glycerol monolaurate comprises about 0.001% (w/v) to about 10% (w/v) of the composition.
8. The composition of claim 1 , wherein glycerol monolaurate is present at a concentration of about 10 μg/mL to about 100 mg/mL.
9. The composition of claim 1 , further comprising an aqueous solvent.
10. The composition of claim 9 , wherein the aqueous solvent is water, saline, media, or a combination thereof.
11. The composition of claim 1 , wherein the pH of said composition is from about 4.0 to about 4.5.
12. The composition of claim 1 , further comprising an accelerant.
13. The composition of claim 12 , wherein the accelerant is an organic acid, a chelator, an antibiotic agent, an anti-fungal agent, an anti-viral agent, or a combination thereof.
14. The composition of claim 12 , wherein the accelerant is EDTA.
15. A composition comprising about 0.005-5% (w/v) glycerol monolaurate, and a non-aqueous gel including about 73% (w/w) propylene glycol, about 25% (w/w) polyethylene glycol, and about 1.25% (w/w) hydroxypropyl cellulose, and having a pH of about 4.0-6.0.