Shape memory polymer
A polymer is composed of a linear chain acrylate and a multi-functional acrylate cross-linker. The polymerized composition exhibits a transition at a temperature between about 34° C. and about 50° C. The polymerized composition exhibits shape memory effects. In one embodiment, the linear chain is tert-butyl acrylate and the crosslinker is polyethylene glycol dimethacrylate. The resultant shape memory polymers may be used in medical devices to provide devices with different shapes for pre and post implantation.
1. An amorphous polymerized composition comprising
a linear chain comprising tert-butyl acrylate; and
a first cross-linker comprising polyethylene glycol dimethacrylate; wherein
the amorphous polymerized composition exhibits a glass transition at a temperature between about 34° C. and about 50° C., inclusive;
the amorphous polymerized composition comprises 5% to 80% by weight of the polyethylene glycol dimethacrylate; and
the amorphous polymerized composition exhibits shape memory effects.
2. The amorphous polymerized composition of claim 1 further comprising a photoinitiator.
3. The amorphous polymerized composition of claim 1 comprising more than about 10% by weight of the polyethylene glycol dimethacrylate.
4. The amorphous polymerized composition of claim 1 , wherein the shape memory polymer comprises 20% by weight of polyethylene glycol dimethacrylate.
5. The amorphous polymerized composition of claim 1 , wherein the glass transition temperature is about 37° C.
6. The amorphous polymerized composition of claim 2 , wherein the photoinitiator comprises 2,2-dimethoxy-2-phenylacetophen one.
7. The amorphous polymerized composition of claim 1 , wherein a recovery time of the amorphous polymerized composition is between 10 seconds and 10 minutes.
8. A device for in vivo medical applications comprising
a chemically-cross-linked, shape memory polymer comprising
tert-butyl acrylate as a first monomer; and
polyethylene glycol dimethacrylate as a second chemically crosslinking monomer; wherein
the shape memory polymer comprises 5% to 80% by weight of polyethylene glycol dimethacrylate;
the shape memory polymer has a glass transition temperature between about 34° C. and 50° C., inclusive;
the device is formed of the shape memory polymer in an original shape;
the device is deformed from the original shape for use in the in vivo medical application; and
the device recovers to the original shape upon being placed in vivo at body temperature.
9. The device of claim 7 , wherein the shape memory polymer comprises 20% by weight of polyethylene glycol dimethacrylate.
10. The device of claim 7 further comprising a photoinitiator.
11. The device of claim 10 , wherein the photoinitiator is 2,2-dimethoxy-2-phenylacetophenone.
12. The device of claim 7 , wherein the shape memory polymer has a glass transition temperature of about 37° C.
13. The device of claim 7 , wherein the shape memory polymer an elastic modulus between 0.5 MPa and 20 MPa, inclusive.
14. The device of claim 7 , wherein a recovery time of the shape memory polymer is between 10 seconds and 10 minutes.
15. The device of claim 7 , wherein recovery time of transformation of the shape memory polymer is a function of a deformation temperature (T d ).
16. The device of claim 7 , wherein the shape memory polymer further comprises a hydrogel material.
17. The device of claim 14 , wherein
the recovery time is a function of an amount of the polyethylene glycol dimethacrylate in the shape memory polymer.
18. The device of claim 7 , wherein selection of an amount of polyethylene glycol dimethacrylate changes the glass transition temperature.