Aminotriazine derivative and pharmaceutical composition comprising the same
The present invention provides novel compounds having a P2X 3 and/or P2X 2/3 receptor antagonistic activity. A compound of Formula (I): wherein R a and R b , and R d and R e are taken together to form oxo or the like; R 4a and R 4b are hydrogen or the like; n is 1 or the like; R 2 is aryl or the like; s and s′ is 0 or the like; R 9 and R 9 ′ are halogen or the like; R 20a and R 20b are hydrogen, alkyl or the like; u is 1 to 4; R 13 is hydrogen or the like, or its pharmaceutically acceptable salt.
1. A compound of formula:
or its pharmaceutically acceptable salt.
2. A pharmaceutical composition comprising the compound according to claim 1 , or its pharmaceutically acceptable salt, and further comprising a pharmaceutical additive.
3. The pharmaceutical composition according to claim 2 , wherein the composition has a P2X 3 and/or P2X 2/3 receptor antagonistic activity.
4. The compound according to claim 1 , chosen from a compound of the following formula:
or its pharmaceutically acceptable salt.
5. The compound according to claim 1 , chosen from a compound of the following formula:
or its pharmaceutically acceptable salt.
6. The compound according to claim 1 , chosen from a compound of the following formula:
or its pharmaceutically acceptable salt.
7. A pharmaceutical composition comprising the compound according to any one of claims 4 , 5 and 6 , or its pharmaceutically acceptable salt, and further comprising a pharmaceutical additive.
8. The pharmaceutical composition according to claim 7 , wherein the composition has a P2X 3 and/or P2X 2/3 receptor antagonistic activity.