IP Library › Granted Patent US 9,745,298
Granted Patent B2
US 9,745,298 · App. 15/147,709 · Granted Aug 29, 2017

Synthesis of a compound that modulates kinases

Inventors: Prabha N. Ibrahim (Mountain View, CA); Masayoshi Jin (Tokyo, JP); Shinji Matsuura (Tokyo, JP)
Assignees: Plexxikon Inc.; Daiichi Sankyo Company, Limited
C07D471/04
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Quick Facts
Patent No.
US 9,745,298
App. No.
15/147,709
Granted
Aug 29, 2017
Kind
B2
Abstract

The present disclosure provides processes for the preparation of a compound of formula I: or a salt thereof, active on the receptor protein kinases c-Kit and/or c-Fms and/or Flt3. The disclosure also provides compounds and processes for the preparation of the compounds that are synthetic intermediates to the compound of formula I.

Claims (6)

1. A compound of formula III:

or a salt thereof, wherein each PG independently is a protecting group wherein the protecting group is independently selected from the group consisting of tert-butyloxycarbonyl, benzyloxycarbonyl and 9-fluorenylmethoxycarbonyl.

2. A compound of formula IIIa:

or a salt thereof.

3. A compound of formula IV:

or a salt thereof.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2022
From: PLEXXIKON INC.
To: DAIICHI SANKYO, INC.
Reel/Frame 060313/0698 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 3, 2016
From: IBRAHIM, PRABHA N.
To: PLEXXIKON INC.
Reel/Frame 039926/0281 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 3, 2016
From: JIN, MASAYOSHI; MATSUURA, SHINJI
To: DAIICHI SANKYO COMPANY, LIMITED
Reel/Frame 039926/0361 →
Continuity (3)
Provisional Application 62241040 · Oct 13, 2015
Provisional Application 62157902 · May 6, 2015
Related Publication 20160326169A1 · Nov 10, 2016