Boron-containing small molecules
This invention relates to, among other items, benzoxaborole compounds and their use for treating bacterial infections.
1. A compound having a structure which is:
wherein R 3 is CH 2 NH 2 ;
R 4 is bromine;
Y is O; and
R 5 is methyl;
C* is a carbon atom stereocenter which has a configuration which is (S) or a salt, hydrate or solvate thereof.
2. A composition comprising:
a) a first stereoisomer of the compound of claim 1 ;
b) at least one additional stereoisomer of the first stereoisomer;
wherein the first stereoisomer is present in an enantiomeric excess of at least 80% relative to said at least one additional stereoisomer.
3. A combination comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, together with at least one other therapeutically active agent.
4. A pharmaceutical formulation comprising:
a) the compound of claim 1 , or a pharmaceutically acceptable salt thereof; and
b) a pharmaceutically acceptable excipient.
5. A method of inhibiting LeuRS, comprising: contacting the LeuRS with the compound of claim 1 , thereby inhibiting the LeuRS.
6. A method of killing and/or preventing the growth of Mycobacterium tuberculosis comprising: contacting the Mycobacterium tuberculosis with an effective amount of the compound of claim 1 , thereby killing and/or preventing the growth of the Mycobacterium tuberculosis.
7. A method of treating and tuberculosis in an animal, comprising: administering to the animal a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically-acceptable salt thereof, thereby treating and/or preventing the tuberculosis.
8. The method of claim 7 , wherein the animal is a human.