IP Library › Granted Patent US 9,757,472
Granted Patent B2
US 9,757,472 · App. 14/808,984 · Granted Sep 12, 2017

Proteas stabilized antibacterial peptides for

Inventors: Chris Diehnelt (Chandler, AZ); Stephen Johnston (Tempe, AZ)
Assignee: Arizona Board of Regents on Behalf of Arizona State University
A61K47/48246A61K38/16C07K7/08
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Quick Facts
Patent No.
US 9,757,472
App. No.
14/808,984
Granted
Sep 12, 2017
Kind
B2
Abstract

Improved peptide compositions and synbody compositions are disclosed that show improved stability and antibiotic activity. The new antibacterial peptides for S. aureus have particular D-amino acid substitutions in order to increase protease stability while also preserving marked antibiotic activity. Thus, compositions and methods for treating infections related to S. aureus also are disclosed.

Claims (8)

1. A bactericidal composition comprising a peptide scaffold ScO:

conjugated to at least one other peptide having at least one D-amino acid.

2. The composition of claim 1 , wherein said composition comprises synbody Ly-Ly-ScO:

wherein lowercase letters represent D amino acids.

3. The composition of claim 1 , wherein said composition is selected from the group consisting of synbody D1-D1-ScO (CSGkkRRHHrrkkRrHHrrK-ScO-CSGkkRRHHrrkkRrHHrrK), synbody D2-D2-ScO (CSGRrkrPrrkrPRrkRPRr-ScO-CSGRrkrPrrkrPRrkRPRr), and synbody D2-88-ScO (CSGRrkrPrrkrPRrkRPRr-ScO-CSGEMWAIMPPIIKPDNKGH), wherein lowercase letters represent D amino acids.

4. A method of treating an S. aureus infection, comprising the step of administering an effective amount of synbody Ly-Ly-ScO:

to an infected subject, wherein lowercase letters represent D amino acids.

5. A method of treating an S. aureus infection, comprising the step of administering an effective amount of synbody D1-D1-ScO, (CSGkkRRHHrrkkRrHHrrK -ScO-CSGkkRRHHrrkkRrHHrrK), synbody D2-D2-ScO (CSGRrkrPrrkrPRrkRPRr-ScO-CSGRrkrPrrkrPRrkRPRr), and synbody D2-88-ScO (CSGRrkrPrrkrPRrkRPRr -ScO-CSGEMWAIMPPIIKPDNKGH), wherein lowercase letters represent D amino acids, to an infected subject, and wherein ScO comprises:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 24, 2015
From: DIEHNELT, CHRIS; JOHNSTON, STEPHEN
To: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Reel/Frame 036174/0879 →
Continuity (2)
Provisional Application 62029948 · Jul 28, 2014
Related Publication 20160022832A1 · Jan 28, 2016