Methods and compositions involving (S)-bucindolol
Disclosed is bucindolol substantially free of its R-stereoisomer. Also disclosed are pharmaceutical compositions that include bucindolol substantially free of its R-stereoisomer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Also disclosed are methods of treating a patient that involve administering to the patient a therapeutically effective amount of a composition of the present invention.
1. A medical device comprising a coating, a matrix, or a chamber, wherein the coating, matrix, or chamber comprises bucindolol substantially free of the R-stereoisomer of the bucindolol.
2. The medical device of claim 1 , wherein the medical device is a stent, a graft, a heart valve, a filter, a catheter, a coil, a mesh repair material, a plate, a rod, a screw, or a suture.
3. The medical device of claim 2 , wherein the medical device is a heart valve.
4. The medical device of claim 2 , wherein the medical device is a stent.
5. The medical device of claim 2 , wherein the medical device is a filter.
6. The medical device of claim 2 , wherein the filter is an inferior vena cava filter.
7. The medical device of claim 2 , wherein the medical device is a catheter.
8. The medical device of claim 7 , wherein the catheter is drug infusion catheter.
9. The medical device of claim 2 , wherein the medical device is a coil.
10. The medical device of claim 9 , wherein the coil is an embolic coil.