Composition and method for treating skin conditions
Provided are biocompatible topical compositions including a novel combination of an inflammatory management agent, a vascular repair agent, a neurogenic agent, a sebum suppression agent and an exfoliating agent. Also provided are methods for treating, preventing or ameliorating rosacea, a symptom thereof or a condition related thereto by administering the biocompatible topical compositions describe herein.
1. A topical composition, comprising:
an inflammatory management agent comprising lactose and/or milk protein, the inflammatory management agent being present in an amount of from about 0.01 wt. % to about 12.5 wt. % based on the weight of the topical composition;
a vascular repair agent comprising palmitoyl glycine, the vascular repair agent being present in an amount of from about 0.01 wt. % to about 15 wt. % based on the weight of the topical composition;
a neurogenic agent comprising an oligosaccharide, the neurogenic agent being present in an amount of from about 0.01 wt. % to about 22.5 wt. % based on the weight of the topical composition;
a sebum suppression agent comprising Panthenyl Triacetate, farnesol and farnesyl acetate, the sebum suppression agent being present in an amount of from about 0.01 wt. % to about 25 wt. % based on the weight of the topical composition; and
an exfoliating agent comprising at least one plant derived cysteine protease enzyme, the exfoliating agent being present in an amount of from about 0.01 wt. % to about 10 wt. % based on the weight of the topical composition.
2. The topical composition according to claim 1 , further comprising one or more agent selected from the group consisting of a solvent, a chelating agent, a humectant, a thickener, emollient, an emulsifier, a skin conditioning agent, an antioxidant, an anti-inflammatory agent, pH adjuster and a preservative.
3. The topical composition of claim 1 , wherein the inflammatory management agent is present in an amount of from about 0.25 wt. % to about 10.0 wt. % based on the weight of the topical composition.
4. The topical composition of claim 1 , wherein the vascular repair agent is present in an amount of from about 0.25 wt. % to about 5.0 wt. % based on the weight of the topical composition.
5. The topical composition of claim 1 , wherein the neurogenic agent is present in an amount of from about 0.1 wt. % to about 5.0 wt. % based on the weight of the topical composition.
6. The topical composition of claim 1 , wherein the sebum suppression agent is present in an amount of from about 0.1 wt. % to about 5.0 wt. % based on the weight of the topical composition.
7. The topical composition of claim 1 , wherein the exfoliating agent is present in an amount of from about 0.1 wt. % to about 10.0 wt. % based on the weight of the topical composition.
8. A topical dosage form selected from the group consisting of a cream, a lotion, an ointment, a foam, an aerosol, a powder, a solution, an emulsion, and a serum, comprising the topical composition according to claim 1 .
9. The topical dosage form of claim 8 , wherein the topical composition does not comprise a fragrance.
10. The topical dosage form of claim 8 , wherein topical dosage form is a lotion.
11. A topical composition, consisting essentially of:
an inflammatory management agent comprising lactose and milk protein, the inflammatory management agent being present in an amount of from about 0.01 wt. % to about 12.5 wt. % based on the weight of the topical composition;
a vascular repair agent comprising palmitoyl glycine, the vascular repair agent being present in an amount of from about 0.01 wt. % to about 15 wt. % based on the weight of the topical composition;
a neurogenic agent comprising an oligosaccharide, the neurogenic agent being present in an amount of from about 0.01 wt. % to about 22.5 wt. % based on the weight of the topical composition;
a sebum suppression agent comprising Panthenyl Triacetate, farnesol and farnesyl acetate, the sebum suppression agent being present in an amount of from about 0.01 wt. % to about 25 wt. % based on the weight of the topical composition;
an exfoliating agent comprising at least one plant derived cystein protease enzyme, the exfoliating agent being present in an amount of from about 0.01 wt. % to about 10 wt. % based on the weight of the topical composition; and
optionally one or more agent selected from the group consisting of a solvent, a chelating agent, a humectant, a thickener, emollient, an emulsifier, a skin conditioning agent, an antioxidant, an anti-inflammatory agent, pH adjuster and a preservative.
12. A kit, comprising the topical composition of claim 1 .
13. The kit of claim 12 , further comprising one or more additional composition selected from the group consisting of a skin cleanser, an organic or an inorganic sunscreen, an exfoliating polish, a topical formulation comprising salicylic acid.
14. A method for treating rosacea, comprising:
topically administering a therapeutically effective amount of the topical composition according to claim 1 to skin of a subject in need thereof.
15. The method of claim 14 , wherein the topical composition is a lotion.
16. The method of claim 14 , wherein administering comprises twice daily application of the topical composition.
17. The method of claim 14 , further comprising cleaning the skin prior to administration of the topical composition.
18. The method of claim 17 , further comprising exfoliating the skin of the subject by administering an exfoliating polish.
19. The method according to claim 17 , further comprising administering a topical formulation comprising salicylic acid to the skin of the subject.
20. The method according to claim 17 , further comprising administering an organic or an inorganic sunscreen to the skin of the subject.