Treatment of obesity
View Patent ↗The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present invention relates to a method of increasing lipid oxidation in a mammal by administering a ligand which interacts with the IL-6 receptor and signals via interaction with a gp130/LIF receptor heterodimer. In a related aspect, the present invention provides a method of increasing insulin sensitivity in a mammal. The method of present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterized by unwanted lipid accumulation (such as obesity, obesity induced-metabolic disorders, type II diabetes, dyslipidemia, glucose intolerance, insulin resistance, obstructive sleep apnea, cardiovascular disease or non-alcoholic fatty liver disease) or inadequate insulin sensitivity.
1. A method for increasing fat oxidation wherein the method comprises administering to the mammal a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 7, which amino acid sequence corresponds to the amino acid sequence of an IL-6/CNTF chimeric polypeptide in which the site III loop of the CNTF replaces the site III loop of IL-6 and which comprises an IL-6 receptor binding site, a gp130 binding site and a LIF receptor binding site that permit the polypeptide to bind the IL-6 receptor and to signal via a gp130/LIF receptor heterodimer.
2. The method according to claim 1 , wherein the mammal is obese and has a condition selected from the group consisting of osteoarthritis, type II diabetes mellitus, hypertension, stroke, and cardiovascular disease.
3. The method of claim 1 , wherein the mammal is a human.