Ultrasound contact fluid
An aqueous ultrasound contact fluid includes a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and the use of the ultrasound contact fluid in an intraoperative or interventional ultrasound imaging procedure. A method for intraoperative ultrasound imaging includes filling an aqueous ultrasound contact fluid into a body cavity. The aqueous ultrasound contact fluid is a composition comprising a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and optionally a pharmaceutically acceptable humectant, and the triglyceride content is in the range of 8-240 g/1000 ml composition contact fluid and the amount of emulsifier is 0.4-18 g/1000 ml composition contact fluid, and optionally a humectant in the amount of 1.2-30 g/1000 ml. The method further includes obtaining an ultrasound image of a body region that comprises at least part of the body cavity filled with the aqueous ultrasound contact fluid. The aqueous ultrasound contact fluid reduces image artifacts associated with the body cavity.
1. A method for intraoperative ultrasound imaging, comprising:
filling a body cavity with an aqueous ultrasound contact fluid,
wherein the aqueous ultrasound contact fluid is a composition comprising a pharmaceutical grade triglyceride and a pharmaceutically acceptable emulsifier and optionally a pharmaceutically acceptable humectant,
wherein the triglyceride content is in the range of 8-240 g/1000 ml contact fluid and the amount of emulsifier is 0.4-18 g/1000 ml contact fluid, and optionally a humectant in the amount of 1.2-30 g/1000 ml; and
obtaining an ultrasound image of a body region that comprises at least part of the body cavity filled with the aqueous ultrasound contact fluid,
wherein the aqueous ultrasound contact fluid reduces image artifacts associated with the body cavity.
2. The method according to claim 1 ,
wherein the amount of triglyceride is in the range of 10-200 g/1000 ml contact fluid, and
wherein the amount of emulsifier is 0.5-15 g/1000 ml contact fluid and optionally a humectant in the amount of 1.2-25 g/1000 ml contact fluid.
3. The method according to claim 1 ,
wherein the amount of triglyceride is 50-110 g/1000 ml contact fluid, the amount of emulsifier is 2-10 g/1000 ml contact fluid, and
optionally a humectant in the amount of 5-15 g/1000 ml contact fluid.
4. The method according to claim 1 , wherein said triglyceride is vegetable oil.
5. The method according to claim 4 , wherein said vegetable oil is selected from the group consisting of soybean oil, olive oil, palm oil, and copra oil.
6. The method according to claim 1 , wherein said emulsifier is selected from the group consisting of lecithin, egg yolk lecithin, soy lecithin, emulsifying wax, cetearyl alcohol, polysorbate 20, and ceteareth 20.
7. The method according to claim 1 , wherein the humectant is selected from the group consisting of glycerol, lactic acid, polyols, propylene glycol, and sorbitol.
8. The method according to claim 1 , wherein the ultrasound contact fluid comprises a pH adjusting additive.
9. The method according to claim 8 , wherein an amount of the pH adjusting additive is added to set the pH in the range of 6 to 8.
10. The method according to claim 9 , wherein the pH is set to 7.
11. The method according to claim 1 , wherein the ultrasound contact fluid comprises 90 g soybean oil, 5.5 g lecithin and 10 g glycerol and physiological saline to obtain 1000 ml.
12. The method according to claim 1 , wherein the ultrasound contact fluid has an attenuation coefficient α>0.066.
13. The method according to claim 12 , wherein the attenuation coefficient α is in the range of 0.20 to 1.10.
14. The method according to claim 13 , wherein the attenuation coefficient α is 0.80.
15. The method according to claim 1 , wherein said triglyceride is an animal fat.
16. The method according to claim 15 , wherein said animal fat is selected from the group consisting of milk fats, fish oils, and fish liver oils.