Stimulation of an immune response by enantiomers of cationic lipids
Compositions and methods for treating immune cells and activating immune responses are disclosed. The compositions comprise one or more optically active chiral cationic lipids.
1. A method of enhancing a DOTAP induced immunostimulatory effect in an immune system of a mammal, said method consisting of the step of administering a chiral cationic lipid consisting of R-DOTAP to the mammal.
2. The method of claim 1 , wherein the immunostimulatory effect includes production of immune system regulatory molecules.
3. The method of claim 2 , wherein the immune system regulatory molecules include at least one cytokine or chemokine.
4. The method of claim 3 , wherein the at least one cytokine or chemokine is selected from CCL-3, CCL-4, CCL-5, CCL-19, IL-2, IL-8, IL-12, or combinations thereof.