Bi-directional motion of a lorentz-force actuated needle-free injector (NFI)
The present invention relate to a method and corresponding apparatus for just in time mixing of a solid or powdered formulation and its subsequent delivery to a biological body. In some embodiments, a powdered formulation is maintained in a first chamber of a plurality of chambers. A plurality of electromagnetic actuators are in communication with the plurality of chambers. The actuators, when activated, generate a pressure within at least the first chamber. The pressure results in mixing of the powdered formulation and a diluent in time for delivering into the biological body.
1. A method for needle-free injection of a drug through a tissue into a biological body, the method comprising:
providing the drug in a chamber of a needle-free injection device;
providing a gas in the chamber; and
after providing the drug and the gas in the chamber, using a bi-directional electromagnetic actuator to drive a piston in the chamber to (1) fluidize the drug in the gas inside the chamber, and (2) to eject the fluidized drug from the chamber through a needle-free injection nozzle as a jet with sufficient pressure to penetrate the tissue of the biological body, wherein fluidizing the drug involves oscillating the piston using the electromagnetic actuator to facilitate fluidization of the drug in the gas.
2. The method of claim 1 , wherein using the bi-directional electromagnetic actuator comprises using a bi-directional Lorentz-Force electromagnetic actuator.
3. The method of claim 1 , wherein the drug is a powdered drug.
4. The method of claim 1 , wherein the drug is a solid particulate material.
5. The method of claim 1 , further comprising supporting the drug inside the chamber on a perforated plate prior to fluidizing the drug in the gas.
6. The method of claim 1 , wherein fluidizing the drug comprises using the bi-directional electromagnetic actuator to vibrate the gas inside the chamber to aid in fluidizing the drug in the gas.