Combination comprising N-acetyl-L-cysteine and its use
A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.
1. A method of administering a hydrogel coating, the method comprising:
exposing the hydrogel coating to bodily fluids, wherein the hydrogel coating consists of one or more excipients and active agents consisting of:
(i) N-acetyl-L-cysteine;
(ii) selenium in the form of selenomethionine; and
(iii) melatonin
and/or physiologically acceptable salts thereof.
2. A method of treating dermatological diseases, the method comprising:
administering to patient in need thereof, a combination consisting of one or more excipients and active agents consisting of:
(i) N-acetyl-L-cysteine;
(ii) selenium in the form of selenomethionine; and
(iii) melatonin
and/or physiologically acceptable salts thereof.
3. The method of claim 2 , wherein N-acetyl-L-cysteine is administered at a dose of 5-45 mg/kg/day, selenomethionine is administered at a dose of 0.4-1.2 μg/kg/day, and melatonin is administered at a dose of 0.02-0.08 mg/kg/day.
4. The method of claim 3 , wherein N-acetyl-L-cysteine is administered at a dose of 20-30 mg/kg/day, selenomethionine is administered at a dose of 0.8 μg/kg/day, and melatonin is administered at a dose of 0.04 mg/kg/day.
5. The method of claim 2 , wherein components (i)-(iii) are administered daily.
6. The method of claim 2 , wherein components (i)-(iii) are administered simultaneously, sequentially, or by separate combinatorial administration.
7. The method of claim 2 , wherein components (i)-(iii) are administered orally or epicutaneously.
8. A method of administering a hydrogel coating, the method comprising:
exposing the hydrogel coating to bodily fluids, wherein the hydrogel coating consists of one or more excipients and active agents consisting of:
(i) N-acetyl-L-cysteine;
(ii) selenium in the form of selenomethionine;
(iii) melatonin; and
(iv) dexamethasone
and/or physiologically acceptable salts thereof.