Oral formulations for counteracting effects of aging
An oral formulation as described herein can comprise pomegranate extract, panax ginseng extract, and c. sinensis , where each is present in an amount effective to counteract and/or prevent effects of aging in a subject when administered to the subject. The effects of aging can include age-related changes in gene expression.
1. A method of counteracting an effect of aging in a subject, comprising administering to the subject an effective amount of an oral formulation comprising pomegranate extract, panax ginseng extract, and Cordyceps sinensis , wherein said administering counteracts the effect in the subject to a greater degree than administering the same amount of any one of pomegranate extract, panax ginseng extract, and Cordyceps sinensis.
2. The method of claim 1 , wherein the effective amount delivers to the subject a daily dose comprising about 0.15 mg/kg to about 30.0 mg/kg of pomegranate extract, about 0.35 mg/kg to about 15 mg/kg of panax ginseng extract, and about 15.0 mg/kg to about 150.0 mg/kg of C. sinensis.
3. The method of claim 1 , wherein the oral formulation includes pomegranate extract at about 0.09 wt % to about 80.32 wt %; C. sinensis at about 13.46 wt % to about 99.67 wt %; and panax ginseng extract at about 0.19 wt % to about 67.72 wt %.
4. The method of claim 1 , wherein the subject is human.
5. The method of claim 1 , wherein the oral formulation further comprises at least one fungal strain selected from Paecilomyces hepialis and Hirsutella sinensis.
6. The method of claim 1 , wherein the panax ginseng extract includes ginsenoside Rb1 and ginsenoside Rg1 at a ratio of about 3:1 to about 5:1.
7. The method of claim 1 , wherein the pomegranate extract includes at least 80 wt % polyphenols.
8. The method of claim 1 , wherein the oral formulation further comprises at least one additive selected from the group consisting of a gum, an anti-caking agent, lecithin, microcrystalline cellulose, silica gel, and flavoring.
9. The method of claim 1 , wherein the oral formulation further comprises at least one additional active agent selected from the group consisting of: Schizandra berry extract, whole grape extract, CoenzymeQ 10 , Rhodiola rosacea extract, Tart cherry extract, and L-carnitine tartrate.
10. The method of claim 1 , wherein the oral formulation is present in a dosage form selected from the group consisting of: capsule, tablet, powder, beverage, wafer, confectionary, chewable, gel, paste, elixir, syrup, drops, and lozenge.
11. The method of claim 1 , wherein the effect is a decline in energy metabolism.
12. The method of claim 1 , wherein the effect is a decline in sexual performance.
13. The method of claim 1 , wherein the effect includes age-related changes in gene expression.
14. The method of claim 13 , wherein the gene expression is for a biomarker of aging.
15. The method of claim 13 , wherein the gene expression occurs in muscle tissue.
16. The method of claim 13 , wherein the gene expression occurs in brain tissue.
17. The method of claim 13 , wherein the formulation counteracts the effect in the subject to a similar or greater degree than caloric restriction in the same subject.