Baulamycins, compositions and methods of use thereof
Provided herein are compositions of compounds of formula (I), methods of inhibiting a bacterial infection by contacting a cell with a composition comprising a compound of formula (I), and methods of isolating compounds of formula (I) from an extract of Streptomyces tempisquensis.
1. A method of inhibiting a nonribosomal peptide synthetase independent siderophore (NIS) synthetase comprising contacting the NIS synthetase with a composition comprising a pharmaceutically acceptable excipient and a compound of formula (I), or a pharmaceutically acceptable salt thereof,
wherein R 1 is a C 1-6 alkyl;
said composition contacted in an amount sufficient to inhibit the NIS synthetase.
2. The method of claim 1 , wherein the NIS synthetase is a Type A NIS synthetase.
3. The method of claim 1 , wherein the NIS synthetase is AsbA or SbnE.
4. The method of claim 1 , wherein the compound of formula (I), or pharmaceutically acceptable salt thereof, has a stereochemistry as shown in formula (IA):
5. The method of claim 1 , wherein the compound of formula (I) has a structure
or a pharmaceutically acceptable salt thereof.
6. The method of claim 1 , wherein the compound of formula (I) has a structure
or a pharmaceutically acceptable salt thereof.