Pyrrolo-pyrrole carbamate and related organic compounds, pharmaceutical compositions, and medical uses thereof

1. A compound represented by Formula (I):

wherein:

A 1 is arylene or heteroarylene, each of which is optionally substituted with 1 or 2 substituents independently selected from the group consisting of halogen, alkyl, haloalkyl, cycloalkyl, hydroxyl, alkoxy, and haloalkoxy;

R 1 is one of the following:

(a) heterocyclyl optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of alkyl, —N(R 7 )C(O)R 8 , —N(R 7 )SO 2 R 8 , —C(O)R 8 , —SO 2 R 8 , oxo, halogen, haloalkyl, hydroxyl, and alkoxy;

(b) aryl, heteroaryl, or a fused heterocyclyl-heteroaryl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, —C(O)R 8 , —SO 2 R 8 , heterocycloalkyl, and alkyl; or

(c) alkyl, halogen, —C(O)N(R 9 )(R 10 ), or -alkylene-heterocyclyl;

R 2 is hydrogen or unsubstituted alkyl;

R 3 is hydrogen, alkyl, or aryl, wherein alkyl or aryl is optionally substituted with 1, 2, or 3 halogen substituents;

R 6 is —O-haloalkyl, —O—C(R 11 )(haloalkyl)C(O)N(R 12 )(R 13 ), or

R 7 is hydrogen or alkyl;

R 8 is alkyl;

R 9 is hydrogen or alkyl;

R 10 is hydrogen, alkyl, aryl, aralkyl, -alkylene-heterocyclyl, or -alkylene-cycloalkyl, wherein alkyl, aryl, aralkyl, -alkylene-heterocyclyl, or -alkylene-cycloalkyl are optionally substituted with 1 or more substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, and haloalkyl; or R 9 and R 10 are taken together with the nitrogen atom to which they are attached to form a 4-7 membered heterocyclic ring;

R 11 is hydrogen or alkyl;

R 12 is hydrogen or alkyl; and

R 13 is alkyl;

wherein the stereochemical configuration at any stereocenter in a compound of Formula (I) is R, S, or a mixture thereof;

or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, or N-oxide thereof.

2. The compound of claim 1 , wherein R 2 is hydrogen.

3. The compound of claim 2 , wherein R 3 is hydrogen.

4. The compound of claim 3 , wherein R 6 is —O-haloalkyl.

5. The compound of claim 4 , wherein R 6 is —O—C(H)(CF 3 ) 2 .

6. The compound of claim 5 , wherein A 1 is phenylene substituted with 1 or 2 substituents independently selected from the group consisting of halogen, alkyl, haloalkyl, cycloalkyl, hydroxyl, alkoxy, and haloalkoxy.

7. The compound of claim 6 , wherein A 1 is phenylene substituted with 1 or 2 substituents independently selected from the group consisting of halogen, methyl, —CF 3 , and —O—CF 3 .

8. The compound of claim 7 , wherein A 1 is phenylene substituted with 1 substituent selected from the group consisting of halogen, methyl, —CF 3 , and —O—CF 3 .

9. The compound of claim 5 , wherein A 1 is a 5-membered or 6-membered heteroarylene substituted with 1 or 2 substituents independently selected from the group consisting of halogen, alkyl, haloalkyl, cycloalkyl, hydroxyl, alkoxy, and haloalkoxy.

10. The compound of claim 9 , wherein A 1 is pyridinylene or pyrazolylene, each of which is substituted with 1 or 2 substituents independently selected from the group consisting of halogen, alkyl, haloalkyl, cycloalkyl, hydroxyl, alkoxy, and haloalkoxy.

11. The compound of claim 8 , wherein R 1 is heterocyclyl optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of alkyl, —N(R 7 )C(O)R 8 , —N(R 7 )SO 2 R 8 , —C(O)R 8 , —SO 2 R 8 , oxo, halogen, haloalkyl, hydroxyl, and alkoxy.

12. The compound of claim 11 , wherein R 1 is tetrahydropyranyl, morpholinyl, piperidinyl, pyrrolidinyl, piperizinyl, or azetidinyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of alkyl, —N(R 7 )C(O)R 8 , —N(R 7 )SO 2 R 8 , —C(O)R 8 , —SO 2 R 8 , and oxo.

13. The compound of claim 8 , wherein R 1 is a heterocyclyl selected from:

each of which is optionally substituted with 1 or 2 substituents independently selected from the group consisting of alkyl, —N(R 7 )C(O)R 8 , —N(R 7 )SO 2 R 8 , —C(O)R 8 , —SO 2 R 8 , and oxo.

14. The compound of claim 8 , wherein R 1 is aryl, heteroaryl, or a fused heterocyclyl-heteroaryl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, heterocycloalkyl, and alkyl.

15. The compound of claim 14 , wherein R 1 is phenyl, pyridinyl, pyrazolyl, or a fused heterocyclyl-heteroaryl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, heterocycloalkyl, and alkyl, wherein the fused heterocyclyl-heteroaryl is:

16. The compound of claim 1 , wherein the compound is 1,1,1,3,3,3-hexafluoropropan-2-yl 5-({1-ethyl-3-[3-(morpholin-4-yl)phenyl]-1H-pyrazol-4-yl}methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((1-methyl-3-phenyl-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-phenyl-1-(propan-2-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-(2-chlorophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(3 -chloro-2-{2-oxa-7-azaspiro[4.4]nonan-7-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(3-phenylphenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(3-methyl-2-{2-oxa-7-azaspiro[4.4]nonan-7-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-(2-chlorophenyl)-1-methyl-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-4-chlorobenzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[1-cyclohexyl-3-(propan-2-yl)-1H-pyrazol-5-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(2-chloro-4-morpholinobenzyl) hexahydro-pyrrolo[3,4-c ]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-(morpholin-4-yl)-3-(trifluoromethyl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-methyl-3-(morpholin-4-yl)phenyl]methy}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(2-(3-acetamidoazetidin-1-yl)-5-chlorobenzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[1-(oxan-4-yl)-3-(propan-2-yl)-1H-pyrazol-5-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-methyl-3-(piperidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(4-chloro-2-(5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)benzyl)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-(azetidin-1-yl)-4-chlorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-(4-acetylpiperazin-1-yl)-4-chlorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(2-phenylphenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-chloro-4-(3-methylmorpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(3-chloro-2-{3-oxa-8-azabicyclo[3.2.1]octan-8-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-(morpholin-4-yl)-2-(trifluoromethoxy)phenyl]methyl }-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-(4-acetylpiperazin-1-yl)-2-chlorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[1-ethyl-3-(pyridin-3-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(2-methyl-3-{2-oxa-7-azaspiro[4.4]nonan-7-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(4-chloro-2-(hexahydrocyclopenta[b][1,4]oxazin-4(4aH)-yl)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl }-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-fluoro-2-(3-methylmorpholin-4-yl)phenyl]methyl }-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-({1-ethyl-3-[4-(morpholin-4-yl)phenyl]-1H-pyrazol-4-yl}methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-(4-acetylpiperazin-1-yl)-4-(propan-2-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-chloro-3-(morpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(2-fluoro-4-morpholinobenzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(4-chloro-2- {5H,6H,7H,8H-imidazo[1,2-a]pyrazin-7-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(4-chloro-2-{5H,6H,7H-pyrrolo[3,4-b]pyridin-6-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-chloro-2-(morpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[1-ethyl-3-(pyridin-4-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-({1-ethyl-3-[4-(pyrrolidin-1-yl)phenyl]-1H-pyrazol-4-yl}methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-(1-methanesulfonylpiperidin-4-yl)-1-(propan-2-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-chloro-2-(3-methylmorpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(4-chloro-2-{1-oxo-2,8-diazaspiro[4.5]decan-8-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-fluoro-4-(3-methylmorpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5- [(4-chloro-2-{8-oxa-2-azaspiro[4.5]decan-2-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-chloro-2-(pyrrolidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-chloro-2-(4-methanesulfonylpiperazin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(2-chloro-3-{2-oxa-7-azaspiro[4.4]nonan-7-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(5-chloro-2-(4-(methylsulfonamido)piperidin-1-yl)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-(4-acetylpiperazin-1-yl)-4-fluorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-fluoro-2-(pyrrolidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-Hexafluoropropan-2-yl 5-(4-chloro-2-((R)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)benzyl)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-methyl-2-(morpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-(1-acetylpiperidin-4-yl)-1-(propan-2-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[2-(morpholin-4-yl)-4-(propan-2-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-(4-acetylpiperazin-1-yl)-2-fluorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[1-(1-acetylpiperidin-4-yl)-3-methyl-1H-pyrazol-5-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(2-(4-acetamidopiperidin-1-yl)-5-chlorobenzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-methyl-1-(propan-2-yl)-1H-pyrazol-5-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-(propan-2-yl)-2-(pyrrolidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-methyl-2-(piperidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((1-ethyl-5-(morpholine-4-carbonyl)-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[bis(4-chlorophenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(4-phenylphenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-fluoro-2-(morpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[4-chloro-2-(morpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-(1-acetylpiperidin-4-yl)-1-methyl-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[3-(1-methanesulfonyl-piperidin-4-yl)-1-methyl-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-({3-[2-(azetidin-1-yl)phenyl]-1-ethyl-1H-pyrazol-4-yl}methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-({1-ethyl-3-[3-(pyrrolidin-1-yl)phenyl]-1H-pyrazol-4-yl}methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-({3-[3-(azetidin-1-yl)phenyl]-1-ethyl-1H-pyrazol-4-yl}methyl)-octahydro-pyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-({3-[4-(azetidin-1-yl)phenyl]-1-ethyl-1H-pyrazol-4-yl}methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-{[1-ethyl-3-(pyridin-2-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((5-(benzylcarbamoyl)-1-ethyl-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-Hexafluoropropan-2-yl 5-((1-ethyl-3-(morpholine-4-carbonyl)-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((3-(benzylcarbamoyl)-1-ethyl-1H-pyrazol-4-yl)methyl)hexa -hydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[2-methyl-3-(piperidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[(3-phenylphenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-(morpholin-4-yl)-2-(trifluoromethoxy) phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[(2-phenylphenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-(2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-4-chlorobenzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-(2-chloro-4-morpholinobenzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-(4-chloro-2-(hexahydrocyclopenta[b][1,4]oxazin-4(4aH)-yl)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[2-chloro-4-(3-methylmorpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-((1-methyl-3-phenyl-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-(2-fluoro-4-morpholinobenzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[bis(4-chlorophenyl) methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[(4-phenylphenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-fluoro-2-(morpholin-4-yl)phenyl]methyl}-octahydro-pyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-fluoro-2-(pyrrolidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-fluoro-2-(3-methylmorpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[2-(4-acetylpiperazin-1-yl)-4-fluorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-chloro-2-(morpholin-4-yl)phenyl]methyl}-octahydro-pyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-chloro-2-(pyrrolidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-chloro-2-(3-methylmorpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[2-(4-acetylpiperazin-1-yl)-4-chlorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[2-(morpholin-4-yl)-4-(propan-2-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-(propan-2-yl)-2-(pyrrolidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[2-(4-acetylpiperazin-1-yl)-4-(propan-2-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[2-fluoro-4-(3-methylmorpholin-4-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-(4-acetylpiperazin-1-yl)-2-fluorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-(4-acetylpiperazin-1-yl)-2-chlorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[3-methyl-2-(piperidin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[(4-chloro-2-{8-oxa-2-azaspiro[4.5]decan-2-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[(4-chloro-2-{5H,6H,7H-pyrrolo[3,4-b]pyridin-6-yl}phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-Dioxopyrrolidin-1-yl 5-(4-chloro-2-(5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)benzyl)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-Dioxopyrrolidin-1-yl 5-(4-chloro-2-((R)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)benzyl)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[4-chloro-2-(4-methane-sulfonylpiperazin-1-yl)phenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[(4-chloro-2-{1-oxo-2,8-diazaspiro[4.5]decan-8-yl}phenyl)methyl]-octahydro-pyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[2-(azetidin-1-yl)-4-chlorophenyl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[3-(2-chlorophenyl)-1-methyl-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[3-(1-acetylpiperidin-4-yl)-1-methyl-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[3-phenyl-1-(propan-2-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[3-(2-chlorophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[3-(1-acetylpiperidin-4-yl)-1-(propan-2-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[3-(1-methanesulfonylpiperidin-4-yl)-1-(propan-2-yl)-1H-pyrazol-4-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[3-methyl-1-(propan-2-yl)-1H-pyrazol-5-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[1-(1-acetylpiperidin-4-yl)-3-methyl-1H-pyrazol-5-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[1-cyclohexyl-3-(propan-2-yl)-1H-pyrazol-5-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-{[1-(oxan-4-yl)-3-(propan-2-yl)-1H-pyrazol-5-yl]methyl}-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,2,2-trifluoro-1-(methylcarbamoyl)ethyl 5-[bis(4-chlorophenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,2,2-trifluoro-1-(methylcarbamoyl)ethyl 5-[(4-phenylphenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(2-methyl-3-[3-oxa-8-azabicyclo[3 .2. 1]octan-8-yl]phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoro-propan-2-yl 5-[(3-[2-oxa-7-azaspiro[4.4]nonan-7-yl]-2-(trifluoromethyl)phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-(morpholin-4-yl)-2-(trifluoromethyl)phenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-([1-ethyl-3-[2-(piperidin-1-yl)phenyl]-1H-pyrazol-4-yl]methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-([1-ethyl-3-[2-(morpholin-4-yl)phenyl]-1H-pyrazol-4-yl]methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-([1-ethyl-3-[3-(piperidin-1-yl)phenyl]-1H-pyrazol-4-yl]methyl)-octahydro-pyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-([1-ethyl-3-[4-(piperidin-1-yl)phenyl]-1H-pyrazol-4-yl]methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(2-[7-methanesulfonyl-2,7-diazaspiro[4.4]nonan-2-yl]phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(2-[7-acetyl-2,7-diazaspiro[4.4]nonan-2-yl]phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(2-[2-methanesulfonyl-2,6-diazaspiro[3.4]octan-6-yl]phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(2-[2-acetyl-2,6-diazaspiro[3.4]octan-6-yl]phenyl)methyl]-octahydropyrrolo [3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[[3-methyl-2-(4-methylpiperazin-1-yl)phenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[[2-(4-ethylpiperazin-1-yl)-3-methylphenyl]methyl]-octahydropyrrolo [3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[[3-(4-methanesulfonamidopiperidin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[[3-(4-methanesulfonylpiperazin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[[3-(4-acetamidopiperidin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo [3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[[3-(4-acetylpiperazin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[[3-(4,4-difluoropiperidin-1-yl)-2-methylphenyl]methyl]octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxocyclopentyl 5-[[2-methyl-3-(4-methylpiperazin-1-yl)phenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxocyclopentyl 5-[[3-(4-ethylpiperazin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-methyl-2-(4-methylpiperazin-1-yl)phenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[2-(4-ethylpiperazin-1-yl)-3-methylphenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-(4-methanesulfonamidopiperidin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-(4-methanesulfonylpiperazin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo [3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-(4-acetamidopiperidin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-(4-acetylpiperazin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-(4,4-difluoropiperidin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo [3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[2-methyl-3-(4-methylpiperazin-1-yl)phenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-(4-ethylpiperazin-1-yl)-2-methylphenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-ethyl-1-(oxan-4-yl)-1H-pyrazol-5-yl]methyl]-octahydropyrrolo [3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-tert-butyl-1-(oxan-4-yl)-1H-pyrazol-5-yl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-chloro-2-(4,4-difluoropiperidin-1-yl)phenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-chloro-2-(4-fluoropiperidin-1-yl)phenyl]methyl]-octahydropyrrolo [3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-[[3-chloro-2-(4-fluoropiperidin-1-yl)phenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-([2-chloro-4-[(piperidin-1-yl)carbonyl]phenyl]methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-(2-chloro-4-(morpholine-4-carbonyl)benzyl)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl5-(2-chloro-4-(pyrrolidine-1-carbonyl)benzyl)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate ; 2,5-dioxopyrrolidin-1-yl 5-(4-(azetidine-1-carbonyl)-2-chlorobenzyl)-hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl5-(2-fluoro-4-(piperidine-1-carbonyl)benzyl)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-(2-fluoro-4-(pyrrolidine-1-carbonyl)benzyl)-hexahydropyrrolo [3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl5-(4-(azetidine-1-carbonyl)-2-fluorobenzyl)-hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[1-(2-chlorophenyl)-3-ethyl-1H-pyrazol-5-yl]methyl]-octahydropyrrolo [3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-tert-butyl-1-(2-chlorophenyl)-1H-pyrazol-5-yl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-chloro-2-(4-methylpiperazin-1-yl)phenyl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(3-chloro-2-[8-oxa-2-azaspiro[4.5]decan-2-yl]phenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5([3-chloro-2-[(3S)-3-(fluoromethyl)pyrrolidin-1-yl]phenyl]methyl)-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[[3-(3-chlorophenyl)-1-(propan-2-yl)-1H-pyrazol-4-yl]methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(2-chlorophenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(3-chlorophenyl)methyl]-octahydropyrrolo [3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-[(4-chlorophenyl)methyl]-octahydropyrrolo[3,4-c]pyrrole-2-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((1-ethyl-3-(prop-2-yn-1-ylcarbamoyl)-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((5-((cyclopropylmethyl)carbamoyl)-1-ethyl-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((5-((3-chlorophenethyl)carbamoyl)-1-ethyl-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((1-ethyl-5-(((tetrahydro-2H-pyran-4-yl)methyl)carbamoyl)-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(3-(morpholinomethyl)-5-(trifluoromethoxy)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(3-(piperidin-1-ylmethyl)-5-(trifluoro-methoxy)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoro-propan-2-yl 5-(3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethoxy)benzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethoxy) benzyl)hexa-hydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoro-propan-2-yl 5-(2-methyl-3-(piperidine-1-carbonyl)benzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(5-(morpholinomethyl)-2-(trifluoromethoxy)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(5-(piperidin-1-ylmethyl)-2-(trifluoromethoxy)benzyl)hexa-hydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(5-(pyrrolidin-1-ylmethyl)-2-(trifluoromethoxy) benzyl)hexa-hydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(4-(morpholine-4-carbonyl)-3-(trifluoro-methoxy)benzyl) hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoro-propan-2-yl 5-(4-(piperidine-1-carbonyl)-3-(trifluoromethoxy)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(4-(pyrrolidine-1-carbonyl)-3-(trifluoromethoxy)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((1-methyl-3-phenyl-1H-pyrazol-5-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((3-(3-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((1-methyl-3-(m-tolyl)-1H-pyrazol-5-yl)methyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-((1-methyl-3-phenyl-1H-pyrazol-5-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-((3-(3-fluorophenyl)-1-methyl-1H-pyrazol-5-yl)methyl)hexa-hydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 2,5-dioxopyrrolidin-1-yl 5-((1-methyl-3-(m-tolyl)-1H-pyrazol-5-yl)methyl)hexa-hydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(2-(difluoromethyl)-4-morpholinobenzyl)hexa-hydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(2-(difluoromethyl)-4-(piperidin-1-yl)benzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(2-(difluoro-methyl)-4-(pyrrolidin-1-yl)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(4-(difluoromethyl)-2-morpholinobenzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(4-(difluoro-methyl)-2-(piperidin-1-yl)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(4-(difluoromethyl)-2-(pyrrolidin-1-yl)benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((6-methyl-[1,1′-biphenyl]-3-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-((1-methyl-3-phenyl-1H-pyrazol-4-yl)methyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(4-chloro-2-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl) benzyl)hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; 1,1,1,3,3,3-hexafluoro-propan-2-yl 5-(2-(tetrahydro-1H-furo[3,4-c]pyrro1-5(3H)-yl)-6-(trifluoromethyl)benzyl) hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; or 1,1,1,3,3,3-hexafluoropropan-2-yl 5-(2-(tetrahydro-1H-furo[3,4-c]pyrrol-5(3H)-yl)-4-(trifluoromethyl)benzyl)hexahydro-pyrrolo[3,4-c]pyrrole-2(1H)-carboxylate; or a pharmaceutically acceptable salt thereof.

17. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, or N-oxide thereof, and a pharmaceutically acceptable carrier.

18. A method of treating pain in a patient, comprising administering a therapeutically effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt, solvate, hydrate, tautomer, or N-oxide thereof, to a patient in need thereof to treat said pain.