Compositions and methods for the treatment of presbyopia
The invention provides compositions and methods for the treatment of presbyopia. The compositions preferably comprise aceclidine and a cycloplegic agent. The compositions optionally contain a surfactant, a viscosity enhancer, an osmolarity modifier and a preservative.
1. An ophthalmological composition for the treatment of presbyopia comprising an active agent consisting of aceclidine and a cycloplegic agent.
2. The ophthalmological composition according to claim 1 , wherein aceclidine is at a concentration from about 0.25% to about 2.0% w/v, wherein w/v denotes weight by volume.
3. The ophthalmological composition according to claim 2 , wherein the cycloplegic agent is tropicamide.
4. A method of treating presbyopia comprising administering to a subject in need thereof the ophthalmological composition of claim 1 .
5. A method of treating irregular astigmatism, keratoconic ectasia, and low myopia, or hyperopia, with or without astigmatism, comprising administering to a subject in need thereof the ophthalmological composition of claim 1 .
6. An ophthalmological composition for the treatment of presbyopia comprising an active agent consisting of aceclidine and about 0.004% to about 0.08% w/v of a cycloplegic agent, wherein w/v denotes weight by volume.
7. The ophthalmological composition according to claim 6 , wherein the cycloplegic agent is at a concentration from about 0.004% to about 0.049% w/v.
8. The ophthalmological composition according to claim 7 , wherein the cycloplegic agent is at a concentration from about 0.004% to about 0.025% w/v.
9. The ophthalmological composition according to claim 6 , wherein aceclidine is at a concentration from about 0.25% to about 2.0% w/v, wherein w/v denotes weight by volume.
10. The ophthalmological composition according to claim 6 , wherein the cycloplegic agent is tropicamide.
11. A method of treating presbyopia comprising administering to a subject in need thereof the ophthalmological composition of claim 6 .
12. A method of treating irregular astigmatism, keratoconic ectasia, and low myopia, or hyperopia, with or without astigmatism, comprising administering to a subject in need thereof the ophthalmological composition of claim 6 .