IP Library › Granted Patent US 9,833,537
Granted Patent B2
US 9,833,537 · App. 13/339,704 · Granted Dec 5, 2017

Calcium-based bone cement formula with enhanced non-dispersive ability

Inventors: Jiin-Huey Chern Lin (Winnetka, IL); Chien-Ping Ju (Kansas City, MO)
Assignee: NATIONAL CHENG KUNG UNIVERSITY
A61L24/0063A61L27/425A61L2400/06A61L2430/02
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Quick Facts
Patent No.
US 9,833,537
App. No.
13/339,704
Granted
Dec 5, 2017
Kind
B2
Abstract

A calcium-based bone cement formula having a powder component and a setting liquid component with a liquid to powder ratio of 0.20 ml/g to 0.50 ml/g is provided, wherein the powder component includes tetracalcium phosphate. The bone cement formula further contains, based on the total weight of the bone cement formula, 0.01-1% of poly(acrylic acid) having a repeating unit of —(CH 2 —C(COOH)H)n-, wherein n=50-50000.

Claims (8)

1. A hardened block of a calcium-based bone cement formula consisting of a powder component, a liquid solution with a liquid to powder ratio of 0.20 ml/g to 0.50 ml/g, and, based on the total weight of the bone cement formula, 0.01-1% of poly(acrylic acid) having a repeating unit of —(CH2-C(COOH)H)n-, wherein n=50-50000, wherein the powder component consists of tetracalcium phosphate (TTCP) and dicalcium phosphate, or the powder component consists of TTCP, dicalcium phosphate and a calcium sulfate source, wherein a molar ratio of the TTCP to the dicalcium phosphate is of about 0.5 to about 2.5, and a content of the calcium sulfate source is of 5-65%, based on the total weight of the TTCP, dicalcium phosphate and the calcium phosphate source, and wherein the calcium sulfate source is calcium sulfate hemihydrate (CSH), calcium sulfate dehydrate (CSD), or anhydrous calcium sulfate,

wherein the liquid solution comprises ammonium ion (NH 4 + ) in a concentration of about 0.075 M to 3 M, and

wherein the liquid solution is a solution of NH 4 H 2 PO 4 , (NH 4 ) 2 HPO 4 , (NH 4 ) 3 PO 4 .3H 2 O, (NH 4 ) 3 PO 4 , or a mixture solution of two or more of NH 4 H 2 PO 4 , (NH 4 ) 2 HPO 4 , (NH 4 ) 3 PO 4 .3H 2 O, and (NH 4 ) 3 PO 4 .

2. The hardened block of bone cement formula of claim 1 , wherein n=1000-5000.

3. The hardened block of bone cement formula of claim 1 , wherein n=1500-2500.

4. The hardened block of bone cement formula of claim 1 , wherein the dicalcium phosphate is dicalcium phosphate anhdydrous (DCPA).

5. The hardened block of bone cement formula of claim 1 , wherein the molar ratio of TTCP to dicalcium phosphate is about 1.0.

6. The hardened block of bone cement formula of claim 1 , wherein the liquid solution is a solution of (NH 4 ) 2 HPO 4 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 20, 2026
From: NATIONAL CHENG KUNG UNIVERSITY
To: JOY MEDICAL DEVICES CORPORATION
Reel/Frame 075586/0936 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 29, 2011
From: LIN, JIIN-HUEY CHERN; JU, CHIEN-PING
To: NATIONAL CHENG KUNG UNIVERSITY
Reel/Frame 027457/0952 →
Priority Claims (1)
TW 100143476 A · Nov 28, 2011 · national
Continuity (1)
Related Publication 20130138114A1 · May 30, 2013