Palladium complex with high anticancer activity
A compound of the formula in which X is an anion selected front F − , CI − , Br − , I − , NO 3 − , CH 3 COO − , CN − , SCN − , NCO − and CIO 4 groups. This formula is obtained by synthezing a [Pd(bpma)Cl]X.H 2 O complex, adding barbiturate salt to the complex and obtaining crystals of the complex.
1. A compound shown in formula (I):
and the letter X is an anion selected front F − , Cl − , Br − , I − , NO 3 − , CH 3 COO − , CN − , SCN − , NCO − and CIO 4 groups, in which an oxidation number of Pd is (II) and the whole complex is +1.
2. A method for obtaining the formula (I) of claim 1 comprising:
synthesizing a [Pd(bpma)Cl]X.H 2 O complex;
obtaining a solution after addition of barbiturate salt to the [Pd(bpma)Cl]X.H 2 O complex; and
obtaining [Pd(bpma)(barb)]X.H 2 O crystals.
3. The method of claim 2 , wherein before the addition of barbiturate salt to the [Pd(bpma)Cl]X.H 2 O complex the steps of:
obtaining a solution with a reflux of water soluble silver salt in water after addition to the synthesized [Pd(bpma)Cl]X.H 2 O complex;
removing AgCl (s) precipitate from the solution; and
evaporating a remaining solution after the removal AgCl (s) precipitate.
4. The method of claim 2 , wherein the method is performed up to 60° C. temperature and for 2 hours.
5. The method of claim 2 , wherein said barbiturate salt is Na(barb).
6. The method of claim 2 , wherein said water soluble silver salt is AgNO 3 .
7. A method of treating a patient suffering from colon cancer comprising administering the compound of claim 1 .
8. The method of claim 7 , wherein said compound is applied parenterally.