Fluorescent polymers and applications thereof
View Patent ↗In one aspect, block copolymers are described herein. A block copolymer described herein, in some embodiments, comprises a first block comprising a polymer or oligomer formed from the reaction product of (i) a polycarboxylic acid or a polycarboxylic acid equivalent, (ii) a polyol, and (iii) an amino acid; and a second block comprising a polymer or oligomer that differs from the polymer or oligomer of the first block. In some cases, the polycarboxylic acid or polycarboxylic acid equivalent comprises citric acid, a citrate, or an ester of citric acid. The polyol can comprise an α,ω-n-alkane diol, poly(ethylene glycol), or poly(propylene glycol). In some embodiments, the amino acid forms a pendant group of the polymer or oligomer of the first block and/or forms a luminescent 6-membered ring with the polycarboxylic acid or polycarboxylic acid equivalent. The second block of a block copolymer described herein, in some embodiments, comprises a polylactone.
1. A micelle formed from an amphiphilic polymer, the amphiphilic polymer comprising:
at least one hydrophilic block comprising a hydrophilic polymer or oligomer; and
at least one hydrophobic block comprising a hydrophobic polymer or oligomer,
wherein the hydrophilic polymer or oligomer and/or the hydrophobic polymer or oligomer is formed from the reaction product of (i) a polycarboxylic acid or a polycarboxylic acid equivalent, (ii) a polyol, and (iii) an amino acid, and
wherein the hydrophilic block and the hydrophobic block are bonded together through an ester linkage;
wherein the micelle has a hydrophobic core and a hydrophilic corona; and
wherein a drug is disposed in the hydrophobic core of the micelle.
2. The micelle of claim 1 , wherein the micelle is a fluorescent micelle.
3. A medical device formed at least in part from the micelle of claim 1 .