Peptide carrier fusion proteins as allergy vaccines
The present invention relates to a polypeptide comprising at least three peptide fragments consisting of 10 to 50 consecutive amino acid residues of at least one wild-type allergen fused to the N- and C-terminus of a surface polypeptide of a virus of the hepadnaviridae family or at least one fragment of said surface polypeptide.
1. A nucleic acid molecule encoding a polypeptide comprising the amino acid sequence selected from the group consisting of SEQ ID No. 14, SEQ ID No. 15, SEQ ID No. 16 and SEQ ID No. 17.
2. A vector, comprising the nucleic acid molecule of claim 1 .
3. The vector of claim 2 , which is an expression vector.
4. The vector of claim 2 , which is a bacterial, fungal, insect, viral or mammalian vector.
5. A host cell, comprising the nucleic acid molecule of claim 1 .
6. A host cell, comprising the vector of claim 2 .
7. A method for treating a grass pollen allergy in a human or animal subject in need thereof, the method comprising administering an effective amount of the nucleic acid molecule of claim 1 to the subject.