Instrumentation amplifier with digitally programmable input capacitance cancellation

1. An instrumentation amplifier device comprising:

an instrumentation amplifier comprising:

a differential input stage comprising an inverting input terminal and a non-inverting input terminal;

an output stage driven by the input stage;

a direct current feedback loop from the output stage to the input stage; and

a negative capacitance generation feedback circuit between the input stage and the direct current feedback loop, wherein a negative capacitance is generated at the input stage to cancel parasitic capacitances at the inverting input terminal and the non-inverting input terminal and thereby boost input impedance, wherein the negative capacitance generation feedback circuit comprises:

a first negative impedance converter circuit connected in parallel between the inverting input terminal and a first internal node of the instrumentation amplifier; and

a second negative impedance converter circuit connected in parallel between the non-inverting terminal and a second internal node of the instrumentation amplifier.

2. The instrumentation amplifier device of claim 1 , wherein gains from the first and second internal nodes are out of phase.

3. The instrumentation amplifier device of claim 1 , wherein each negative impedance converter circuit comprises a plurality of programmable capacitors disposed in parallel.

4. The instrumentation amplifier device of claim 3 , wherein the instrumentation amplifier is calibratable by setting each programmable capacitor to be on or off to maximize the input impedance boosting.

5. The instrumentation amplifier device of claim 1 , wherein the negative capacitance generation feedback circuit cancels at least in part input capacitance to the input stage generated by one or more of an electrode cable, a printed circuit board, and an integrated circuit package connected to the input stage.

6. The instrumentation amplifier device of claim 1 , wherein the negative capacitance generation feedback circuit is operable to boost the input impedance to at least 100 MΩ, and the instrumentation amplifier is operable to measure input biosignals having frequencies of up to at least 50 Hz.

7. An instrumentation amplifier device, comprising:

an instrumentation amplifier comprising:

a differential input stage comprising an inverting input terminal and a non-inverting input terminal;

an output stage driven by the input stage;

a direct current feedback loop from the output stage to the input stage;

a negative capacitance generation feedback circuit between the input stage and the direct current feedback loop, and including programmable capacitors to generate the negative capacitance at the inverting input terminal and the non-inverting input terminal of the instrumentation amplifier; and

a calibration circuit comprising a processor operative in a calibration mode to:

measure voltage at an output node of the instrumentation amplifier or of a subsequent gain or filtering stage;

compare the measured voltage amplitude to a plurality of reference voltages;

generate a respective plurality of control signals responsive to the comparison; and

transmit the generated control signals to control the programmable capacitors of the instrumentation amplifier to optimize the negative capacitance generated at the input terminals of the instrumentation amplifier.

8. The instrumentation amplifier device of claim 7 , wherein the calibration circuit includes:

an analog-to-digital converter operative to provide the reference voltages, and

a calibration unit comprising input ports to receive input signals from the analog to digital converter, a plurality of output ports to transmit control signals to switches at the programmable capacitors, and memory to store a code representative of a control signal to optimize the negative capacitance.

9. The instrumentation amplifier device of claim 7 , wherein the calibration circuit includes a test current generator operative to inject a test current having a selected magnitude into the input of the instrumentation amplifier to generate a voltage at the output node.

10. A method of measuring biosignals comprising:

receiving biosignals at an input stage of an instrumentation amplifier, the input stage including an inverting input terminal and a non-inverting input terminal;

generating an amplified output signal at an output stage of the instrumentation amplifier;

generating within the instrumentation amplifier a feedback loop from the output stage to the input stage; and

boosting impedance at the input stage by generating a negative capacitance in the feedback loop from a first negative impedance converter circuit connected in parallel between the inverting input terminal and a first internal node of the instrumentation amplifier and a second negative impedance converter circuit connected in parallel between the non-inverting terminal and a second internal node of the instrumentation amplifier.

11. The method of claim 10 , wherein the first and second internal nodes have out of phase gains.

12. A method of measuring biosignals comprising:

receiving biosignals at an input stage of an instrumentation amplifier, the input stage including an inverting input terminal and a non-inverting input terminal;

generating an amplified output signal at an output stage of the instrumentation amplifier;

generating within the instrumentation amplifier a feedback loop from the output stage to the input stage;

boosting impedance at the input stage by generating a negative capacitance in the feedback loop;

connecting electrode cables to the input stage of the instrumentation amplifier; and

calibrating the negative capacitance converter circuitry after connecting the electrode cables to maximize the boosting of the impedance at the input stage.

13. The method of claim 12 , wherein the negative capacitance converter circuitry comprises a plurality of programmable capacitors, and the calibrating step comprises setting each of the programmable capacitors to on or off.

14. The method of claim 10 , further comprising:

connecting electrode cables to each of the inverting input terminal and the non-inverting input terminal, the electrode cables connected to dry electrodes; and

receiving voltages representative of electroencephalography or electrocardiography signals.

15. The method of claim 10 , further comprising boosting the impedance to at least 100 MΩ.

16. An instrumentation amplifier device comprising:

an instrumentation amplifier comprising

a differential input stage comprising an inverting input terminal and a non-inverting input terminal;

an output stage driven by the input stage;

a direct current feedback loop from the output stage to the input stage; and

a negative capacitance generation feedback circuit between the input stage and the direct current feedback loop, wherein a negative capacitance is generated at the input stage to cancel parasitic capacitances at the inverting input terminal and the non-inverting input terminal and thereby boost input impedance at the inverting input terminal and the non-inverting input terminal;

wherein the negative capacitance generation feedback circuit is connected in parallel between the input stage and internal nodes of the instrumentation amplifier, and gains from the internal nodes are out of phase, creating a differential-mode signal.