Granted Patent
B2
US 9,855,318 · App. 15/140,519 · Granted Jan 2, 2018
Fusion proteins
Inventors:
David Bruce Baldwin (Carmel, IN); John Michael Beals (Indianapolis, IN); Jonathan Wesley Day (Carmel, IN); Craig Duane Dickinson (San Diego, CA); Andrew Ihor Korytko (Oceanside, CA); Gregory Alan Lazar (Pacifica, CA)
Assignee:
Eli Lilly and Company
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Abstract
The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.
Claims (4)
1. A homodimer of two fusion proteins of having the amino acid sequence of SEQ ID NO: 12.
2. A pharmaceutical composition comprising the homodimer of claim 1 .
3. A method of treating a patient with diabetes mellitus comprising administering to a patient in need thereof the homodimer of claim 1 .
4. A fusion protein having the amino acid sequence of SEQ ID NO: 12.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 23, 2026
From: BALDWIN, DAVID BRUCE; BEALS, JOHN MICHAEL; DAY, JONATHAN WESLEY; DICKINSON, CRAIG DUANE; KORYTKO, ANDREW IHOR; LAZAR, GREGORY ALAN
To: ELI LILLY AND COMPANY
Reel/Frame 073566/0155 →
Continuity (2)
Provisional Application
62158079
· May 7, 2015