2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide, polymorphic forms thereof, methods for preparation and use thereof, pharmaceutical compositions thereof, and kits and articles of manufacture thereof.
1. A polymorphic form of a compound of the formula:
wherein the polymorphic form is crystalline, of an X-ray powder diffraction pattern (CuKα) comprising peaks at about 10.601, 11.638, 12.121, 13.021, 13.435, 15.418, 15.760, 17.830, 18.753, and 19.671° 2θ.
2. The polymorphic form of claim 1 , wherein the polymorphic form of a compound of the formula:
wherein the polymorphic form is crystalline, having an X-ray powder diffraction pattern (CuKα) comprising peaks at ±0.1 of 10.601, 11.638, 12.121, 13.021, 13.435, 15.418, 15.760, 17.830, 18.753, and 19.671° 2θ.
3. A polymorphic form of a compound of the formula:
wherein the polymorphic form is crystalline, having an X-ray powder diffraction pattern (CuKα) comprising peaks at about 7.552, 10.339, 11.159, 12.107, 14.729, 15.329, 15.857, 16.824, 17.994, 18.344, 19.444, 19.764, 20.801, and 22.414° 2θ.
4. The polymorphic form of claim 3 , wherein the polymorphic form of a compound of the formula:
wherein the polymorphic form is crystalline, having an X-ray powder diffraction pattern (CuKα) comprising peaks at ±0.1 of 7.552, 10.339, 11.159, 12.107, 14.729, 15.329, 15.857, 16.824, 17.994, 18.344, 19.444, 19.764, 20.801, and 22.414° 2θ.
5. A pharmaceutical composition comprising:
an active ingredient comprising a polymorphic form of a compound according to claim 1 or claim 3 , and
a pharmaceutically acceptable carrier.
6. The pharmaceutical composition according to claim 5 , wherein the pharmaceutical composition is formulated for administration: orally, intraadiposally, intraarterially, intraarticularly, intracranially, intradermally, intralesionally, intramuscularly, intranasally, intraocularly, intrapericardially, intraperitoneally, intrapleurally, intraprostatically, intrarectally, intrathecally, intratracheally, intratumorally, intraumbilically, intravaginally, intravenously, intravesicularlly, intravitreally, liposomally, locally, mucosally, parenterally, rectally, subconjunctival, subcutaneously, sublingually, topically, transbuccally, transdermally, vaginally, in crémes, in lipid compositions, via a catheter, via a lavage, via continuous infusion, via infusion, via inhalation, via injection, via local delivery, or via localized perfusion.
7. The pharmaceutical composition of claim 6 , wherein the pharmaceutical composition is formulated for oral, intraarterial, intravenous or topical administration.
8. The pharmaceutical composition according to claim 6 , wherein the pharmaceutical composition is formulated for oral administration.
9. The pharmaceutical composition according to claim 5 , wherein the pharmaceutical composition is formulated as a hard or soft capsule, a tablet, a syrup, a suspension, a solid dispersion, a wafer, or an elixir.
10. The pharmaceutical composition according to claim 5 , further comprising an agent that enhances solubility and dispersibility.
11. The pharmaceutical composition according to claim 5 , wherein the compound or polymorphic form is suspended in sesame oil.
12. The pharmaceutical composition according to claim 5 , wherein the pharmaceutical composition is formulated for topical administration.
13. The pharmaceutical composition of claim 12 , wherein pharmaceutical composition is formulated as a lotion, a cream, a gel, an oil, an ointment, a salve, or a suspension.
14. The pharmaceutical composition of claim 13 , wherein the pharmaceutical composition is formulated as a lotion.
15. The pharmaceutical composition of claim 13 , wherein the pharmaceutical composition is formulated as a cream.
16. The pharmaceutical composition of claim 13 , wherein the pharmaceutical composition is formulated as a gel.
17. The pharmaceutical composition of claim 5 , wherein the amount of the active ingredient is from about 0.01% to about 5% by weight.
18. The pharmaceutical composition of claim 17 , wherein the amount of the active ingredient is from about 0.01% to about 3% by weight.
19. The pharmaceutical composition of claim 18 , wherein the amount of the active ingredient is about 0.01% by weight.
20. The pharmaceutical composition of claim 18 , wherein the amount of the active ingredient is about 0.1% by weight.
21. The pharmaceutical composition of claim 18 , wherein the amount of the active ingredient is about 1% by weight.
22. The pharmaceutical composition of claim 18 , wherein the amount of the active ingredient is about 3% by weight.