5-β, 14-β-androstane derivatives useful for the treatment of proteinuria, glomerulosclerosis and renal failure
View Patent ↗Compound of formula (I), wherein the symbol have the meaning reported in the text; for preparing a medicament for the prevention and/or treatment of proteinuria, glomerulosclerosis or renal failure.
1. A method for treating proteinuria, comprising the step of administering to a normotensive patient in need thereof a therapeutically effective amount of a compound of formula (I),
wherein:
the symbol represents a single bond;
Y is OR 4 and has an alpha or a beta configuration;
R is 3-furyl;
R 1 is hydrogen;
R 2 is hydrogen;
R 3 is hydrogen;
R 4 is hydrogen.
2. The method according to claim 1 , wherein the compound is administered in a dose of from 0.05 mg to 20 mg per day.
3. The method according to claim 2 , wherein the compound is administered in a dose of from 0.5 mg to 15 mg.
4. The method according to claim 3 , wherein the compound is administered in a dose of from 5 mg to 10 mg.
5. The method according to claim 4 , wherein the compound is administered) in a single dose schedule.
6. The method according to claim 4 , wherein the compound is administered in a multiple dose schedule.
7. The method according to claim 1 , wherein the compound is administered to the patient orally, intravenously, intramuscularly, intra-arterially, intramedullary, intrathecally, intraventricularly, transdermally, transcutaneously, subcutaneously, intraperitoneally, intranasally, enterally, topically, sublingually or rectally.
8. A method of antagonizing podocyte protein loss in a normotensive patient in need thereof, which comprises administering to said patient a therapeutically effective amount of a compound of formula (I),
wherein:
the symbol represents a single bond;
Y is OR 4 and has an alpha or a beta configuration;
R is 3-furyl;
R 1 is hydrogen;
R 2 is hydrogen;
R 3 is hydrogen;
R 4 is hydrogen.