IP Library › Granted Patent US 9,868,935
Granted Patent B2
US 9,868,935 · App. 14/397,122 · Granted Jan 16, 2018

Composition and method of stem cells for preservation of cardiac tissue

Inventors: Lino Da Silva Ferreira (Coimbra, PT); Isabel Maria Fidalgo Dos Santos Silva Carvalho (Braga, PT)
Assignee: CRIOESTAMINAL, SAÚDE E TECNOLOGIA, SA.
C12N5/0647A01N1/0226A61K9/06A61K35/28A61K47/24A61K47/42C12N2500/02C12N2500/36C12N2501/999C12N2533/56
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Quick Facts
Patent No.
US 9,868,935
App. No.
14/397,122
Granted
Jan 16, 2018
Kind
B2
Abstract

The present disclosure describes a method and composition for enhancing the survival of hematopoietic stem cells, preferably CD34+ derived from human umbilical cord or peripheral blood, in hypoxic and serum-deprived conditions by cultivating the cells in medium containing lysophosphatidic acid, preferably further comprising a gel, namely a biomimetic gel. The method and composition may be used in medicine or cosmetic application, in particular, in treatment of cardiac tissue and/or cardiac diseases, and/or in the treatment of wound healing namely diabetic wound healing.

Claims (2)

1. A method for enhancing the survival of hematopoietic stem cells in hypoxic and serum-deprived conditions, the method comprising cultivating the hematopoietic stem cells in a medium containing lysophosphatidic acid, wherein the concentration of lysophosphatidic acid is 100 μM, so as to enhance the survival of the hematopoietic stem cells in hypoxic and serum-deprived conditions.

2. The method according to claim 1 wherein the hematopoietic stem cells are CD34+ cells.

Assignments (2)
CHANGE OF NAME Recorded Sep 25, 2015
From: CRIOESTAMINAL-SAÚDE E TECNOLOGIA, S.A.
To: STEMLAB, S.A.
Reel/Frame 036659/0548 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 7, 2014
From: DA SILVA FERREIRA, LINO; FIDALGO DOS SANTOS SILVA CARVALHO, ISABEL MARIA
To: CRIOESTAMINAL, SAÚDE E TECNOLOGIA, SA.
Reel/Frame 034124/0951 →
Priority Claims (1)
PT 106267 · Apr 24, 2012 · national
Continuity (1)
Related Publication 20150139962A1 · May 21, 2015