Anion-paired cationic metallocene-containing compounds and polymers as antimicrobial agents
Anion-paired metallocene-containing compounds are generally provided, along with methods of making the same. In one embodiment, the anion-paired metallocene-containing compound includes a cationic metallocene moiety covalently connected to an organic functional group, and an anion paired to the cationic metallocene moiety. Generally, the cationic metallocene moiety comprises two cyclopentadienyl anions bound to a metal center in the oxidation state I.
1. A anion-paired metallocene-containing polymer, comprising; at least one monomeric unit comprising a cationic metallocene moiety paired to an anion, wherein the cationic metallocene moiety comprises two cyclopentadienyl anions bound to a metal center in the oxidation state I, and wherein the anion comprises an anionic antibiotic compound.
2. The anion-paired metallocene-containing polymer of claim 1 , wherein the anion comprises a hexafluorophosphate anion, a tetraphenylborate anion, a tetrafluoroborate anion, a trifluoromethanesulfonate anion, F—, Cl—, Br—, I—, NO3-, an acetate anion, a sulfate anion, a hydrogen sulfate anion, a perchlorate anion, a bromate anion, a cyanide anion, a thiocyanate anion, a hydroxide anion, a dihydrogen phosphate anion, or a formate anion.
3. The anion-paired metallocene-containing polymer of claim 1 , wherein the anionic antibiotic compound comprises a penicillin anion or related compound, a carbapenem anion or related compound, or a cephalosporin anion or related compound.
4. The anion-paired metallocene-containing polymer of claim 1 , wherein the metal center comprises comprises iron, cobalt, rhodium, or ruthenium.
5. The anion-paired metallocene-containing polymer of claim 1 , wherein the anion-paired metallocene-containing polymer is a homopolymer.
6. The anion-paired metallocene-containing polymer of claim 1 , wherein the anion-paired metallocene-containing polymer is a copolymer comprising the at least one monomeric unit comprising the cationic metallocene moiety paired to the anion and a comonomeric unit.