Cationic lipid
The present invention provides a cationic lipid which can be used for nucleic acid delivery to a cytoplasm and which is possible to solve the problem of physical stability of a lipid complex. This cationic lipid is a compound represented by the general formula (3) or a pharmaceutically acceptable salt thereof: wherein, L is an alkyl having 7-12 carbon atoms or an alkenyl having 7-12 carbon atoms, R is an alkyl having 1-2 carbon atoms, and n 1 and n 2 are independently an integer of 1-3.
1. A cationic lipid which is a compound represented by formula (3) or a pharmaceutically acceptable salt thereof:
wherein L is an alkyl having 7-12 carbon atoms or an alkenyl having 7-12 carbon atoms,
R is an alkyl having 1-2 carbon atoms, and
n 1 and n 2 are each 2.
2. The cationic lipid according to claim 1 , wherein the cationic lipid is a compound selected from the following compounds (4), (6), and (8)-(11) or a pharmaceutically acceptable salt thereof:
3. The cationic lipid according to claim 1 , wherein the cationic lipid is a compound represented by the following formula (4) or a pharmaceutically acceptable salt thereof:
4. The cationic lipid according to claim 1 , wherein the cationic lipid is a compound represented by the following formula (10) or a pharmaceutically acceptable salt thereof: