IP Library › Granted Patent US 9,884,841
Granted Patent B2
US 9,884,841 · App. 15/134,098 · Granted Feb 6, 2018

Small molecule inhibitors of Mcl-1 and uses thereof

Inventors: Zaneta Nikolovska-Coleska (Ann Arbor, MI); Jeanne A. Stuckey (Fenton, MI); Ahmed Mady (Ann Arbor, MI); Lei Miao (Ann Arbor, MI)
Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
C07D333/34A61K31/167A61K31/18A61K31/415A61K31/44A61K31/443A61K31/4409A61K31/4439A61K31/451A61K31/495A61K31/496A61K31/5355A61K45/06C07C229/64C07C233/81C07C235/56C07C311/21C07C311/29C07C323/63C07D295/26
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Quick Facts
Patent No.
US 9,884,841
App. No.
15/134,098
Granted
Feb 6, 2018
Kind
B2
Abstract

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having benzoic acid structure which function as inhibitors of Mcl-1 protein, and their use as therapeutics for the treatment of cancer and other diseases.

Claims (3)

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt, solvate, thereof.

2. A composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.

Assignments (2)
CONFIRMATORY LICENSE Recorded Apr 13, 2018
From: UNIVERSITY OF MICHIGAN
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 045531/0370 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 21, 2016
From: NIKOLOVSKA-COLESKA, ZANETA; STUCKEY, JEANNE A.; MADY, AHMED; MIAO, LEI
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Reel/Frame 038341/0861 →
Continuity (2)
Provisional Application 62149987 · Apr 20, 2015
Related Publication 20160304485A1 · Oct 20, 2016